Evidence map›Paper›PMID 36801564›Full record

ArticleTalanta2023

Gold-binding peptide as a selective layer for electrochemical detection of SARS-CoV-2 antibodies.

Beatriz A Braz, Manuel Hospinal-Santiani, Gustavo Martins, Jeferson L Gogola, Marcia G P Valenga, Breno C B Beirão, Márcio F Bergamini, Luiz H Marcolino-Junior, Vanete Thomaz-Soccol, Carlos R Soccol

Open access · greenAbstract read
In one paragraph

Article in Talanta, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Beatriz A BrazLaboratory of Electrochemical Sensors (LabSensE), Department of Chemistry, Federal University of Paraná (UFPR), CEP 19032, CEP, 81531-980, Curitiba, PR, Brazil; Molecular Biology Laboratory, Graduate Program in Bioprocess Engineering and Biotechnology, Federal University of Paraná (UFPR), CEP, 81531-980, Curitiba, PR, Brazil.
Manuel Hospinal-SantianiMolecular Biology Laboratory, Graduate Program in Bioprocess Engineering and Biotechnology, Federal University of Paraná (UFPR), CEP, 81531-980, Curitiba, PR, Brazil.
Gustavo MartinsLaboratory of Electrochemical Sensors (LabSensE), Department of Chemistry, Federal University of Paraná (UFPR), CEP 19032, CEP, 81531-980, Curitiba, PR, Brazil.
Jeferson L GogolaLaboratory of Electrochemical Sensors (LabSensE), Department of Chemistry, Federal University of Paraná (UFPR), CEP 19032, CEP, 81531-980, Curitiba, PR, Brazil.
Marcia G P ValengaLaboratory of Electrochemical Sensors (LabSensE), Department of Chemistry, Federal University of Paraná (UFPR), CEP 19032, CEP, 81531-980, Curitiba, PR, Brazil.
Breno C B BeirãoGraduate Program in Microbiology, Parasitology, and Pathology, Federal University of Paraná (UFPR), CEP, 81531-980, Curitiba, PR, Brazil.
Márcio F BergaminiLaboratory of Electrochemical Sensors (LabSensE), Department of Chemistry, Federal University of Paraná (UFPR), CEP 19032, CEP, 81531-980, Curitiba, PR, Brazil. Electronic address: bergamini@ufpr.br.
Luiz H Marcolino-JuniorLaboratory of Electrochemical Sensors (LabSensE), Department of Chemistry, Federal University of Paraná (UFPR), CEP 19032, CEP, 81531-980, Curitiba, PR, Brazil. Electronic address: luiz1berto@ufpr.br.
Vanete Thomaz-SoccolMolecular Biology Laboratory, Graduate Program in Bioprocess Engineering and Biotechnology, Federal University of Paraná (UFPR), CEP, 81531-980, Curitiba, PR, Brazil.
Carlos R SoccolMolecular Biology Laboratory, Graduate Program in Bioprocess Engineering and Biotechnology, Federal University of Paraná (UFPR), CEP, 81531-980, Curitiba, PR, Brazil.
Universidade Federal do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electrochemical immunosensors are excellent alternatives to prepare portable platforms used for rapid and inexpensive diagnostic of infectious diseases such as the recently emerged COVID-19. Incorporating synthetic peptides as selective recognition layers combined with nanomaterials such as gold nanoparticles (AuNPs) can significantly enhance the analytical performance of immunosensors. In the present study, an electrochemical immunosensor based on solid-binding peptide was built and evaluated towards SARS-CoV-2 Anti-S antibodies detection. The peptide used as recognition site has two important portions: one based on the viral receptor binding domain (RBD), capable of recognizing antibodies of the spike protein (Anti-S), and another suitable for interacting with gold nanoparticles. Gold-binding peptide (Pept/AuNP) dispersion was used directly to modify a screen-printed carbon electrode (SPE). The voltammetric behavior of the [Fe(CN)

Indexed as

Biosensing TechniquesCOVID-19Metal NanoparticlesAntibodies, ViralElectrochemical TechniquesGoldHumansImmunoassayOrganoplatinum CompoundsPeptidesSARS-CoV-21,10-phenanthroline-platinum(II)-ethylenediamineAntibodies, ViralGoldOrganoplatinum CompoundsPeptidesElectrochemical immunosensorGold nanoparticlesSARS-CoV-2Solid-binding peptide

Identifiers

PMID36801564
PMCPMC9918321
OpenAlexW4319868798

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.