Evidence map›Paper›PMID 36801492›Full record

ArticleThe journal of allergy and clinical immunology. In practice2023

Food Allergy Characteristics Associated With Coexisting Eosinophilic Esophagitis in FARE Registry Participants.

Katharine M Guarnieri, Nicholas K Saba, Justin T Schwartz, Ashley L Devonshire, Jennifer Bufford, Thomas B Casale, Marc E Rothenberg, Sandra Andorf

Open access · greenAbstract read
In one paragraph

Article in The journal of allergy and clinical immunology. In practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Observational
  3. Review
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  6. Review
  7. Review
  8. Epidemiologic and Clinical Clues to the Etiology of Eosinophilic Esophagitis.Immunology and allergy clinics of North America · 2024
    Review
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Katharine M GuarnieriDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Nicholas K SabaDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Justin T SchwartzDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Ashley L DevonshireDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Jennifer BuffordFood Allergy Research & Education, McLean, Va.
Thomas B CasaleFood Allergy Research & Education, McLean, Va; Division of Allergy and Immunology, University of South Florida, Tampa, Fla.
Marc E RothenbergDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Sandra AndorfDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Electronic address: sandra.andorf@cchmc.org.
Cincinnati Children's Hospital Medical Center · USFood Allergy Research and Education · USUniversity of South Florida · US

Funding

KL2 Training ProgramKL2TR001426 · NCATS · UNIVERSITY OF CINCINNATI · PI ZELLER, MARGARET H · 2015 to 2024
$6.8M
Extension of clinical data structured into the ImmPort model and cross-study data exploration and visualization user interfaceUH2AI145837 · NIAID · STANFORD UNIVERSITY · PI ANDORF, SANDRA · 2019 to 2020
$434k
NCATS NIH HHS KL2 TR001426NIAID NIH HHS UH2 AI145837
6 · The paper itself

Abstract

backgroundEosinophilic esophagitis (EoE) can coexist in individuals with food allergy.

objectiveTo evaluate the characteristics of food-allergic patients with and without coexisting EoE using a large food allergy patient registry.

methodsData were derived from 2 Food Allergy Research & Education, Inc, Patient Registry surveys. A series of multivariable regression models were used to evaluate associations between demographic, comorbidity, and food allergy characteristics and the likelihood of reporting EoE.

resultsFive percent (n = 309) of registry participants (n = 6074; ages <1 year->80 years, mean, 20.20 ± 15.37 years) reported having EoE. The odds of having EoE were significantly greater in male participants (adjusted odds ratio [aOR], 1.3; 95% CI, 1.04-1.72) and those with comorbid asthma (aOR, 2.0; 95% CI, 1.55-2.49), allergic rhinitis (aOR, 1.8; 95% CI, 1.37-2.22), oral allergy syndrome (aOR, 2.8; 95% CI, 2.09-3.70), food protein-induced enterocolitis syndrome (aOR, 2.5; 95% CI, 1.34-4.84), and hyper-IgE syndrome (aOR, 7.6; 95% CI, 2.93-19.92), though not atopic dermatitis (aOR, 1.3; 95% CI, 0.99-1.59), when adjusting for demographics (sex, age, race, ethnicity, and geographic location). Those with a greater number of food allergies (aOR, 1.3; 95% CI, 1.23-1.32), more frequent food-related allergic reactions (aOR, 1.2; 95% CI, 1.11-1.24), previous anaphylaxis (aOR, 1.5; 95% CI, 1.15-1.83), and health care utilization for food-related allergic reactions (aOR, 1.3; 95% CI, 1.01-1.67)-specifically intensive care unit admission (aOR, 1.2; 95% CI, 1.07-1.33)-were more likely to have EoE after controlling for demographics. However, no significant difference in ever using epinephrine for food-related allergic reactions was detected.

conclusionsThese self-reported data showed that coexisting EoE is associated with an increased number of food allergies, food-related allergic reactions per year, and measures of reaction severity, calling attention to the likely increased health care needs of food-allergic patients with EoE.

Indexed as

AsthmaEosinophilic EsophagitisFood HypersensitivityRhinitis, AllergicAllergensFemaleHumansInfantMaleRegistriesAllergensComorbiditiesEosinophilic esophagitisFood allergyFood allergy patient registryFood-related allergic reactions

Identifiers

PMID36801492
PMCPMC10164686
OpenAlexW4321254017

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.