Evidence map›Paper›PMID 36801181›Full record

ArticleUltrasound in medicine & biology2023

Magnetic Resonance Thermometry Targeting for Magnetic Resonance-Guided Histotripsy Treatments.

Dinank Gupta, Dave Choi, Ning Lu, Steven P Allen, Timothy L Hall, Douglas C Noll, Zhen Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. MR-Cavitation Dynamics Encoded (MR-CaDE) imaging.Magnetic resonance in medicine · 2025
    Article
  5. Magnetic Resonance Acoustic Radiation Force Imaging (MR-ARFI).Journal of magnetic resonance imaging : JMRI · 2025
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dinank GuptaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Dave ChoiDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Ning LuDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Steven P AllenDepartment of Electrical and Computer Engineering, Brigham Young University, Provo, UT, USA.
Timothy L HallDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Douglas C NollDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Zhen XuDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. Electronic address: zhenx@umich.edu.

Funding

Novel Ultrasonic Technique for the Treatment of Hemorrhagic StrokeR01NS108042 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PANDEY, ADITYA S · 2018 to 2022
$2.6M
Transcranial Magnetic Resonance guided Histotripsy (tcMRgHt)R01EB028309 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, ZHEN · 2019 to 2022
$2.4M
Non-invasive Transcranial Histotripsy Treatment in a Murine Primary Malignant Brain Tumor ModelR21CA260684 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PANDEY, ADITYA S, XU, ZHEN · 2021 to 2021
$384k
NCI NIH HHS R21 CA260684NIBIB NIH HHS R01 EB028309NINDS NIH HHS R01 NS108042
6 · The paper itself

Abstract

objectiveThe potential of transcranial magnetic resonance (MR)-guided histotripsy for brain applications has been described in prior in vivo studies in the swine brain through an excised human skull. The safety and accuracy of transcranial MR-guided histotripsy (tcMRgHt) rely on pre-treatment targeting guidance. In the work described here, we investigated the feasibility and accuracy of using ultrasound-induced low-temperature heating and MR thermometry for histotripsy pre-treatment targeting in ex vivo bovine brain.

methodsA 15-element, 750-kHz MRI-compatible ultrasound transducer with modified drivers that can deliver both low-temperature heating and histotripsy acoustic pulses was used to treat seven bovine brain samples. The samples were first heated to an approximately 1.6°C temperature increase at the focus, and MR thermometry was used to localize the target. Once the targeting was confirmed, a histotripsy lesion was generated at the focus and visualized on post-histotripsy MR images. DISCUSSION: The accuracy of MR thermometry targeting was evaluated with the mean/standard deviation of the difference between the locus of peak heating identified by MR thermometry and the center of mass of the post-treatment histotripsy lesion, which was 0.59/0.31 mm and 1.31/0.93 mm in the transverse and longitudinal directions, respectively.

conclusionThis study determined that MR thermometry could provide reliable pre-treatment targeting for transcranial MR-guided histotripsy treatment.

Indexed as

High-Intensity Focused Ultrasound AblationThermometryAnimalsCattleHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopySkullSwineUltrasonographyHistotripsyMagnetic resonance thermometryTherapeuticUltrasound brain

Identifiers

PMID36801181
PMCPMC10938365

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.