ArticleDevelopmental cell2023
Runx1 controls auditory sensory neuron diversity in mice.
Article in Developmental cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Characteristics and Cell Lineage Tracing of Neurod1-Cre and Neurod1-iCreER Mice Targeting Cochlear Neurons.Neuroscience bulletin · 2026Article
- Molecularly defined auditory neuron subtypes show different vulnerabilities to noise- and age-related synaptopathy in mice.Nature communications · 2026Article
- Foxg1 regulates the development of microvillous cells in the olfactory epithelium.Developmental biology · 2026Article
- Subtype-Specific Vulnerability of Spiral Ganglion Neurons in Sensorineural Hearing Loss Across the Lifespan.Brain sciences · 2026Review
- Conditional Deletion of Isl1 Disrupts Cochlear Sensory and Neuronal Development, Leading to Hearing Loss.Molecular neurobiology · 2026Article
- Regulatory Networks Driving the Specification, Differentiation, and Diversification of Neurons in the Mouse Inner Ear.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- Molecular heterogeneity of the non-human primate cochlea.Nature communications · 2026Article
- The Dual Role of RUNX1 in Inflammation-Driven Age-Related Diseases: From Molecular Mechanisms to Clinical Translation.Biomedicines · 2025Review
- RSK4 promotes the metastasis of clear cell renal cell carcinoma by activating RUNX1-mediated angiogenesis.Cancer biology & therapy · 2025Article
- Probing the role of synaptic adhesion molecule RTN4RL2 in setting up cochlear connectivity.eLife · 2025Article
- Molecularly defined auditory neuron subtypes show different vulnerabilities to noise- and age-related synaptopathy in mice.Research square · 2025Article
- Molecularly defined auditory neuron subtypes show different vulnerabilities to noise- and age-related synaptopathy in mice.bioRxiv : the preprint server for biology · 2025Article
- Combinatorial transcriptional regulation establishes subtype-appropriate synaptic properties in auditory neurons.Cell reports · 2025Article
- Developmental differentiation of mouse inner ear neuron subpopulations resolved with a peripherin-promoter reporter within the Grm8 locus.Scientific reports · 2025Article
- Molecular Cascades That Build and Connect Auditory Neurons from Hair Cells to the Auditory Cortex.Journal of experimental neurology · 2025Article
- A primate model animal revealed the inter-species differences and similarities in the subtype specifications of the spiral ganglion neurons.Scientific reports · 2024Article
- Harmony in the Molecular Orchestra of Hearing: Developmental Mechanisms from the Ear to the Brain.Annual review of neuroscience · 2024Review
- Priming central sound processing circuits through induction of spontaneous activity in the cochlea before hearing onset.Trends in neurosciences · 2024Review
- [Latest Findings on the Role of RUNX1 in Bone Development and Disorders].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Review
- Identification of common stria vascularis cellular alteration in sensorineural hearing loss based on ScRNA-seq.BMC genomics · 2024Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Sound stimulus is encoded in mice by three molecularly and physiologically diverse subtypes of sensory neurons, called Ia, Ib, and Ic spiral ganglion neurons (SGNs). Here, we show that the transcription factor Runx1 controls SGN subtype composition in the murine cochlea. Runx1 is enriched in Ib/Ic precursors by late embryogenesis. Upon the loss of Runx1 from embryonic SGNs, more SGNs take on Ia rather than Ib or Ic identities. This conversion was more complete for genes linked to neuronal function than to connectivity. Accordingly, synapses in the Ib/Ic location acquired Ia properties. Suprathreshold SGN responses to sound were enhanced in Runx1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.