Evidence map›Paper›PMID 36800896›Full record

ArticleAIDS research and human retroviruses2023

Association Between Time to Antiretroviral Therapy and Loss to Care Among Newly Diagnosed Rwandan People Living with Human Immunodeficiency Virus.

Gad Murenzi, Hae-Young Kim, Qiuhu Shi, Benjamin Muhoza, Athanase Munyaneza, Gallican Kubwimana, Eric Remera, Sabin Nsanzimana, Marcel Yotebieng, Denis Nash and 2 more

Abstract read
In one paragraph

Article in AIDS research and human retroviruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Treatment Outcomes After Offering Same-Day Initiation of Human Immunodeficiency Virus Treatment-How to Interpret Discrepancies Between Different Studies.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gad MurenziRwanda Military Hospital, Kigali, Rwanda.ORCID 0000-0002-5513-5522
Hae-Young KimNew York Medical College, Valhalla, New York, USA.
Qiuhu ShiNew York Medical College, Valhalla, New York, USA.
Benjamin MuhozaRwanda Military Hospital, Kigali, Rwanda.
Athanase MunyanezaRwanda Military Hospital, Kigali, Rwanda.
Gallican KubwimanaRwanda Military Hospital, Kigali, Rwanda.
Eric RemeraRwanda Biomedical Center, Kigali, Rwanda.
Sabin NsanzimanaRwanda Biomedical Center, Kigali, Rwanda.
Marcel YotebiengAlbert Einstein College of Medicine, Bronx, New York, USA.
Denis NashInstitute for Implementation Science in Population Health, City University of New York, New York, New York, USA.
Kathryn AnastosAlbert Einstein College of Medicine, Bronx, New York, USA.
Jonathan RossAlbert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0001-6126-3048

Funding

"Enhancing Cancer Research in Central Africa IeDEA"U01AI096299 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Denis Nash, Marcel Yotebieng · 2011 to 2026
$35.8M
Patient and Population Health Outcomes Research SWGP30AI124414 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Kathryn M. Anastos · 2017 to 2026
$28.3M
Shared ResourcesU54CA190163 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ANASTOS, KATHRYN M., CASTLE, PHILIP E · 2014 to 2019
$4.1M
Minimizing losses from HIV care under universal treatment in RwandaK23MH114752 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ROSS, JONATHAN · 2017 to 2021
$995k
NCI NIH HHS U54 CA190163NIAID NIH HHS P30 AI124414NIAID NIH HHS U01 AI096299NIMH NIH HHS K23 MH114752
6 · The paper itself

Abstract

Despite improved clinical outcomes of initiating antiretroviral therapy (ART) soon after diagnosis, conflicting evidence exists regarding the impact of same-day ART initiation on subsequent clinical outcomes. We aimed to characterize the associations of time to ART initiation with loss to care and viral suppression in a cohort of newly diagnosed people living with HIV (PLHIV) entering care after Rwanda implemented a national "Treat All" policy. We conducted a secondary analysis of routinely collected data of adult PLHIV enrolling in HIV care at 10 health facilities in Kigali, Rwanda. Time from enrollment to ART initiation was categorized as same day, 1-7 days, or >7 days. We examined associations between time to ART and loss to care (>120 days since last health facility visit) using Cox proportional hazards models, and between time to ART and viral suppression using logistic regression. Of 2,524 patients included in this analysis, 1,452 (57.5%) were women and the median age was 32 (interquartile range: 26-39). Loss to care was more frequent among patients who initiated ART on the same day (15.9%), compared with those initiating ART 1-7 days (12.3%) or >7 days (10.1%),

Indexed as

Anti-HIV AgentsHIV InfectionsAdultFemaleHIVHumansMaleProportional Hazards ModelsRwandaAnti-HIV AgentsART initiationHIVloss to careretention in careTreat Allviral suppression

Identifiers

PMID36800896
PMCPMC10171964

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.