Evidence map›Paper›PMID 36800507›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2023

Mitochondrial haplotype modulates genome expression and mitochondrial structure/function in cardiomyocytes following volume overload.

Jason L Guichard, Mariame Selma Kane, Maximiliano Grenett, Michael Sandel, Gloria A Benavides, Wayne E Bradley, Pamela Cox Powell, Victor Darley-Usmar, Scott W Ballinger, Louis J Dell'Italia

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jason L GuichardDivision of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0002-7381-5177
Mariame Selma KaneDivision of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Maximiliano GrenettDivision of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Michael SandelWildlife, Fisheries, and Aquaculture, Mississippi State University, Starkville, Mississippi, United States.
Gloria A BenavidesDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Wayne E BradleyDivision of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Pamela Cox PowellDivision of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Victor Darley-UsmarDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Scott W BallingerDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0003-0300-9820
Louis J Dell'ItaliaDivision of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0001-6654-0665
University of Alabama at Birmingham · USMississippi State University · US

Funding

TISSUE RENIN ANGIOTENSIN/CHYMASE SYSTEM IN HEART FAILURER01HL054816 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DELL'ITALIA, LOUIS JOSEPH · 1995 to 2005
$1.6M
Mitochondrial Haplotype Influences LV Dysfunction in Heart FailureR01HL109785 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DARLEY-USMAR, VICTOR M, DELL'ITALIA, LOUIS J. · 2012 to 2015
$1.4M
NHLBI NIH HHS R01 HL054816NHLBI NIH HHS R01 HL109785
6 · The paper itself

Abstract

Mitochondrial DNA (mtDNA) haplotype regulates mitochondrial structure/function and reactive oxygen species in aortocaval fistula (ACF) in mice. Here, we unravel the mitochondrial haplotype effects on cardiomyocyte mitochondrial ultrastructure and transcriptome response to ACF in vivo. Phenotypic responses and quantitative transmission electron microscopy (TEM) and RNA sequence at 3 days were determined after sham surgery or ACF in vivo in cardiomyocytes from wild-type (WT) C57BL/6J (C57

Indexed as

Heart FailureMyocytes, CardiacAnimalsDNA, MitochondrialHaplotypesHumansMiceMice, Inbred C3HMice, Inbred C57BLMitochondriaDNA, Mitochondrialcardiomyocytesmitochondria haplotypepathway analysisreserve capacityvolume overload

Identifiers

PMID36800507
PMCPMC10010923
OpenAlexW4321186223

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.