Evidence map›Paper›PMID 36800506›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2023

Blood pressure and muscle sympathetic nerve activity are associated with trait anxiety in humans.

Jeremy A Bigalke, John J Durocher, Ian M Greenlund, Manda Keller-Ross, Jason R Carter

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

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  6. Individuals with posttraumatic stress disorder have increased beat-to-beat blood pressure variability.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
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  10. α2δ-1-NMDAR1 complex in the hypothalamic paraventricular nucleus mediates anxiety-induced sympathetic hyperactivity.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
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  18. The insular cortex, autonomic asymmetry and cardiovascular control: looking at the right side of stroke.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jeremy A BigalkeDepartment of Health and Human Development, Montana State University, Bozeman, Montana, United States.ORCID 0000-0002-1653-4563
John J DurocherDepartment of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, Michigan, United States.ORCID 0000-0003-4618-1807
Ian M GreenlundDepartment of Psychology, Montana State University, Bozeman, Montana, United States.ORCID 0000-0003-1808-9966
Manda Keller-RossDivision of Physical Therapy and Rehabilitation Science, University of Minnesota, Minneapolis, Minnesota, United States.ORCID 0000-0001-9363-5379
Jason R CarterDepartment of Health and Human Development, Montana State University, Bozeman, Montana, United States.ORCID 0000-0001-7350-6537
Michigan Technological University · USPurdue University Northwest · USUniversity of Minnesota · US

Funding

Research Core (Developmental Research Project Program)P20GM103474 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Ann Therese Bertagnolli · 2012 to 2026
$60.0M
Tracking and Evaluation CoreU54GM115371 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI KREBS, JOCELYN E · 2016 to 2020
$20.9M
NRSA Training CoreTL1TR002318 · NCATS · UNIVERSITY OF WASHINGTON · PI Megan Moore · 2017 to 2026
$8.4M
Alcohol and Neurovascular Control in HumansR01AA024892 · NIAAA · MONTANA STATE UNIVERSITY - BOZEMAN · PI CARTER, JASON R · 2017 to 2021
$1.8M
Autonomic regulation of blood pressure in premature and early menopausal womenK01AG064038 · NIA · UNIVERSITY OF MINNESOTA · PI KELLER-ROSS, MANDA LINEA · 2020 to 2024
$647k
Mindfulness and Neural Cardiovascular Control in HumansR15HL140596 · NHLBI · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI LARSON, ROBERT ARNOLD · 2018 to 2018
$466k
Vasomotor symptoms of menopause and cardiovascular disease: What is the link?R21AG080503 · NIA · UNIVERSITY OF MINNESOTA · PI KELLER-ROSS, MANDA LINEA · 2023 to 2024
$413k
NCATS NIH HHS TL1 TR002318NHLBI NIH HHS R15 HL140596NIAAA NIH HHS R01 AA024892NIA NIH HHS K01 AG064038NIA NIH HHS R21 AG080503NIGMS NIH HHS P20 GM103474NIGMS NIH HHS U54 GM115371
6 · The paper itself

Abstract

Chronic anxiety is prevalent and associated with an increased risk of cardiovascular disease. Prior studies that have reported a relationship between muscle sympathetic nerve activity (MSNA) and anxiety have focused on participants with anxiety disorders and/or metabolic syndrome. The present study leverages a large cohort of healthy adults devoid of cardiometabolic disorders to examine the hypothesis that trait anxiety severity is positively associated with resting MSNA and blood pressure. Resting blood pressure (BP) (sphygmomanometer and finger plethysmography), MSNA (microneurography), and heart rate (HR; electrocardiogram) were collected in 88 healthy participants (52 males, 36 females, 25 ± 1 yr, 25 ± 1 kg/m

Indexed as

Cardiovascular DiseasesAdultAnxietyAnxiety DisordersBaroreflexBlood PressureFemaleHeart RateHumansMaleMusclesMuscle, SkeletalSympathetic Nervous Systemanxietyblood pressurehypertensionmuscle sympathetic nerve activitystress

Identifiers

PMID36800506
PMCPMC10259854
OpenAlexW4321185939

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.