Evidence map›Paper›PMID 36800417›Full record

ArticleScience advances2023

Interactive nanocluster compaction of the ELKS scaffold and Cacophony Ca

Tina Ghelani, Marc Escher, Ulrich Thomas, Klara Esch, Janine Lützkendorf, Harald Depner, Marta Maglione, Pierre Parutto, Scott Gratz, Tanja Matkovic-Rachid and 6 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 49 citations in OpenAlex.

  1. Temporal and Cell-Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  5. Review
  6. Active Zone Maturation Controls Presynaptic Output and Release Mode and Is Regulated by Neuronal Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  7. Article
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  9. Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. A specific negatively charged sequence confers intramolecular regulation on Munc13-1 function in synaptic exocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Review
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  15. Article
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  18. CaeLife · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 5 countries.

Tina GhelaniInstitute for Biology and Genetics, Freie Universität Berlin, Takustraße 6, 14195 Berlin, Germany.ORCID 0000-0003-1835-4686
Marc EscherInstitute for Biology and Genetics, Freie Universität Berlin, Takustraße 6, 14195 Berlin, Germany.ORCID 0000-0001-8952-0843
Ulrich ThomasDepartment of Cellular Neurobiology, Leibniz Institute for Neurobiology, Brenneckestr. 6, 39118 Magdeburg, Germany.ORCID 0000-0002-4372-8611
Klara EschInstitute for Biology and Genetics, Freie Universität Berlin, Takustraße 6, 14195 Berlin, Germany.ORCID 0000-0002-0729-4713
Janine LützkendorfInstitute for Biology and Genetics, Freie Universität Berlin, Takustraße 6, 14195 Berlin, Germany.ORCID 0000-0001-5051-6281
Harald DepnerInstitute for Biology and Genetics, Freie Universität Berlin, Takustraße 6, 14195 Berlin, Germany.ORCID 0000-0002-5285-0248
Marta MaglioneInstitute for Biology and Genetics, Freie Universität Berlin, Takustraße 6, 14195 Berlin, Germany.
Pierre ParuttoGroup of Applied Mathematics and Computational Biology, IBENS, Ecole Normale Superieure, Paris, France.ORCID 0000-0002-9866-407X
Scott GratzDepartment of Neuroscience, Brown University, Providence, RI 02912, USA.ORCID 0000-0002-0106-8336
Tanja Matkovic-RachidInstitute for Biology and Genetics, Freie Universität Berlin, Takustraße 6, 14195 Berlin, Germany.
Stefanie RyglewskiInstitute of Developmental Biology and Neurobiology, Johannes Gutenberg University Mainz, Mainz, Germany.ORCID 0000-0002-3066-6298
Alexander M WalterMolecular and Theoretical Neuroscience Leibniz-Forschungs Institut für Molekulare Pharmakologie (FMP) im CharitéCrossOver (CCO) Charité-University Medicine Berlin Charité Campus Mitte, Charité Platz, 110117 Berlin, Germany.ORCID 0000-0001-5646-4750
David HolcmanGroup of Applied Mathematics and Computational Biology, IBENS, Ecole Normale Superieure, Paris, France.ORCID 0000-0001-9854-5014
Kate O'Connor GilesDepartment of Neuroscience, Brown University, Providence, RI 02912, USA.ORCID 0000-0002-2259-8408
Martin HeineInstitute of Developmental Biology and Neurobiology, Johannes Gutenberg University Mainz, Mainz, Germany.ORCID 0000-0002-0886-3113
Stephan J SigristInstitute for Biology and Genetics, Freie Universität Berlin, Takustraße 6, 14195 Berlin, Germany.ORCID 0000-0002-1698-5815
Freie Universität Berlin · DEJohannes Gutenberg University Mainz · DEUniversity of Cambridge · GBAllen Institute for Brain Science · USBrown University · USLeibniz Institute for Neurobiology · DEUniversity of Copenhagen · DK

Funding

Molecular mechanisms of synapse assembly and functionR01NS078179 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI O'CONNOR-GILES, KATHALEEN M · 2013 to 2023
$3.6M
NINDS NIH HHS R01 NS078179
6 · The paper itself

Abstract

At presynaptic active zones (AZs), conserved scaffold protein architectures control synaptic vesicle (SV) release by defining the nanoscale distribution and density of voltage-gated Ca

Indexed as

Drosophila ProteinsSynapsesAnimalsDrosophilaSynaptic TransmissionSynaptic VesiclesDrosophila Proteins

Identifiers

PMID36800417
PMCPMC9937578
OpenAlexW4321185632

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.