Evidence map›Paper›PMID 36800350›Full record

ArticlePloS one2023

An expression and function analysis of the CXCR4/SDF-1 signalling axis during pituitary gland development.

Jose Mario Gonzalez-Meljem, Sarah Ivins, Cynthia Lilian Andoniadou, Paul Le Tissier, Peter Scambler, Juan Pedro Martinez-Barbera

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Jose Mario Gonzalez-MeljemTecnologico de Monterrey, School of Engineering and Sciences, Mexico City, Mexico.ORCID 0000-0002-1554-0363
Sarah IvinsDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL-Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
Cynthia Lilian AndoniadouDivision of Craniofacial Development and Stem Cell Biology, King's College London, Guy's Hospital, London, United Kingdom.
Paul Le TissierCentre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom.
Peter ScamblerDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL-Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
Juan Pedro Martinez-BarberaDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL-Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
University College London · GBGuy's Hospital · GBUniversity of Edinburgh · GB

Funding

Cancer Research UK 27727Department of HealthMedical Research Council MR/M000125/1Medical Research Council MR/R006237/1
6 · The paper itself

Abstract

The chemokine SDF-1 (CXCL12) and its receptor CXCR4 control several processes during embryonic development such as the regulation of stem cell proliferation, differentiation, and migration. However, the role of this pathway in the formation of the pituitary gland is not understood. We sought to characterise the expression patterns of CXCR4, SDF-1 and CXCR7 at different stages of pituitary gland development. Our expression profiling revealed that SDF-1 is expressed in progenitor-rich regions of the pituitary anterior lobe, that CXCR4 and CXCR7 have opposite expression domains and that CXCR4 expression is conserved between mice and human embryos. We then assessed the importance of this signalling pathway in the development and function of the murine pituitary gland through conditional deletion of CXCR4 in embryonic pituitary progenitors. Successful and specific ablation of CXCR4 expression in embryonic pituitary progenitors did not lead to observable embryonic nor postnatal defects but allowed the identification of stromal CXCR4+ cells not derived from HESX1+ progenitors. Further analysis of constitutive SDF-1, CXCR7 and CXCR4 mutants of the pathway indicates that CXCR4 expression in HESX1+ cells and their descendants is not essential for normal pituitary development in mice.

Indexed as

Receptors, CXCRAnimalsCell DifferentiationChemokine CXCL12Embryo, MammalianFemaleHomeodomain ProteinsHumansMicePregnancyReceptors, CXCR4Repressor ProteinsSignal TransductionChemokine CXCL12Cmkor1 protein, mouseCxcl12 protein, mouseCXCR4 protein, humanCXCR4 protein, mouseHesx1 protein, mouseHomeodomain ProteinsReceptors, CXCRReceptors, CXCR4Repressor Proteins

Identifiers

PMID36800350
PMCPMC9937476
OpenAlexW4321165323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.