Evidence map›Paper›PMID 36800312›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2023

Association Between Contrast Sensitivity and Physical Function in Cognitively Healthy Older Adults: The Brain Networks and Mobility Function Study.

Atalie C Thompson, Haiying Chen, Michael E Miller, Christopher C Webb, Jeff D Williamson, Anthony P Marsh, Christina E Hugenschmidt, Laura D Baker, Paul J Laurienti, Stephen B Kritchevsky

Open access · bronzeAbstract read
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Evaluation of Functional Impacts of Vision Impairment: Progress, Challenges and Future Directions.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Review
  4. Article
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  6. Relationship Between Visual Functions and Independence in ADLs and IADLs Among Community-Dwelling Older Adults.The American journal of occupational therapy : official publication of the American Occupational Therapy Association · 2025
    Article
  7. Article
  8. Article
  9. Relationship of Multiple Sensory Impairments With Physical Performance in Older Adults in the Study of Muscle, Mobility and Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Atalie C ThompsonWake Forest Claude D. Pepper Center, Winston-Salem, North Carolina, USA.ORCID 0000-0002-2817-6417
Haiying ChenWake Forest Claude D. Pepper Center, Winston-Salem, North Carolina, USA.
Michael E MillerWake Forest Claude D. Pepper Center, Winston-Salem, North Carolina, USA.
Christopher C WebbWake Forest Claude D. Pepper Center, Winston-Salem, North Carolina, USA.
Jeff D WilliamsonWake Forest Claude D. Pepper Center, Winston-Salem, North Carolina, USA.
Anthony P MarshWake Forest Claude D. Pepper Center, Winston-Salem, North Carolina, USA.
Christina E HugenschmidtWake Forest Claude D. Pepper Center, Winston-Salem, North Carolina, USA.
Laura D BakerDepartment of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Paul J LaurientiWake Forest Claude D. Pepper Center, Winston-Salem, North Carolina, USA.
Stephen B KritchevskyWake Forest Claude D. Pepper Center, Winston-Salem, North Carolina, USA.ORCID 0000-0003-3336-6781
Wake Forest University · US

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LEON LENCHIK · 2002 to 2026
$36.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3M
Combining assessment of cognition, eye movement, and gait in naturalistic settings to differentiate subclinical Alzheimer's pathology.R01AG052419 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KRITCHEVSKY, STEPHEN B., LAURIENTI, PAUL · 2017 to 2022
$4.2M
Deep learning to quantify glaucomatous damage on fundus photographs for teleophthalmologyK23EY030897 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI THOMPSON, ATALIE C · 2020 to 2024
$968k
NCATS NIH HHS UL1 TR001420NEI NIH HHS K23 EY030897NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG072947NIA NIH HHS R01 AG052419
6 · The paper itself

Abstract

backgroundTo evaluate whether contrast sensitivity is associated with lower extremity physical function in cognitively intact older adults.

methodsCross-sectional analysis of the relationship of binocular and worse eye log contrast sensitivity (LCS) to expanded Short Physical Performance Battery (eSPPB) and its components (gait speed, narrow walking speed, chair stand pace, and balance) in 192 cognitively healthy older adults. The association of LCS with postural sway and gait was also tested with tasks that further challenged functional reserve.

resultsMean age was 76.4 years with 56% identifying as female and over 98.5% having good corrected visual acuity. Lower LCS was significantly associated with worse performance on the eSPPB, 4-M gait speed, narrow walking speed, and balance time in unadjusted and adjusted models. The relationship between worse eye LCS and larger postural sway was 3 times greater on a foam surface (beta 1.07, 95% CI [0.35, 1.80]) than a firm surface (beta 0.35, 95% CI [0.05, 0.65]), and both were robust to adjustment for confounders; similar findings were observed with binocular LCS. Lower binocular LCS had a greater decremental effect on gait velocity during the fast pace (beta -0.58, 95% CI [-0.90, -0.27]) than the usual pace (Beta -0.39 [-0.63, -0.15]) gait task.

conclusionsThese findings suggest that cognitively unimpaired older adults without significant visual acuity impairment can have subtle preclinical deficits in contrast sensitivity and physical function that could place them at risk of mobility and balance issues. Future studies should determine whether this subset of older adults may benefit from targeted intervention to prevent disability.

Indexed as

BrainContrast SensitivityAgedCross-Sectional StudiesFemaleGaitHealth StatusHumansPostural BalanceWalking SpeedBalanceCognitive agingContrast sensitivityGaitPhysical function

Identifiers

PMID36800312
PMCPMC10395565
OpenAlexW4321152758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.