ArticleThe Journal of clinical endocrinology and metabolism2023
Opportunistic Evaluation of Trabecular Bone Texture by MRI Reflects Bone Mineral Density and Microarchitecture.
Article in The Journal of clinical endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Comparative evaluation of sand sources based on physical and morphological characteristics for cement concrete applications.Scientific reports · 2026Article
- Bone texture by clinical magnetic resonance imaging is directly related to bone tissue maturity by Fourier-transform infrared spectroscopy.JBMR plus · 2025Article
- Effects of nonstationary system blur on radiomic texture features of trabecular bone in normal and ultra-high resolution CT.Medical physics · 2025Article
- Radiomics and machine learning for osteoporosis detection using abdominal computed tomography: a retrospective multicenter study.BMC medical imaging · 2025Article
- Individuals with heterogenous trabecular bone texture by clinical magnetic resonance imaging have lower bone strength and stiffness by quantitative computed tomography-based finite element analysis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Integrating deep learning and machine learning for improved CKD-related cortical bone assessment in HRpQCT images: A pilot study.Bone reports · 2025Article
- CORR Insights®: Do Hounsfield Units From Intraoperative CT Scans Correlate With Preoperative Values?Clinical orthopaedics and related research · 2024Article
- Pre-operative bone quality deficits and risk of complications following spine fusion surgery among postmenopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
contextMany individuals at high risk for fracture are never evaluated for osteoporosis and subsequently do not receive necessary treatment. Utilization of magnetic resonance imaging (MRI) is burgeoning, providing an ideal opportunity to use MRI to identify individuals with skeletal deficits. We previously reported that MRI-based bone texture was more heterogeneous in postmenopausal women with a history of fracture compared to controls.
objectiveThe present study aimed to identify the microstructural characteristics that underlie trabecular texture features.
methodsIn a prospective cohort, we measured spine volumetric bone mineral density (vBMD) by quantitative computed tomography (QCT), peripheral vBMD and microarchitecture by high-resolution peripheral QCT (HRpQCT), and areal BMD (aBMD) by dual-energy x-ray absorptiometry. Vertebral trabecular bone texture was analyzed using T1-weighted MRIs. A gray level co-occurrence matrix was used to characterize the distribution and spatial organization of voxelar intensities and derive the following texture features: contrast (variability), entropy (disorder), angular second moment (ASM; uniformity), and inverse difference moment (IDM; local homogeneity).
resultsAmong 46 patients (mean age 64, 54% women), lower peripheral vBMD and worse trabecular microarchitecture by HRpQCT were associated with greater texture heterogeneity by MRI-higher contrast and entropy (r ∼ -0.3 to 0.4, P < .05), lower ASM and IDM (r ∼ +0.3 to 0.4, P < .05). Lower spine vBMD by QCT was associated with higher contrast and entropy (r ∼ -0.5, P < .001), lower ASM and IDM (r ∼ +0.5, P < .001). Relationships with aBMD were less pronounced.
conclusionMRI-based measurements of trabecular bone texture relate to vBMD and microarchitecture, suggesting that this method reflects underlying microstructural properties of trabecular bone. Further investigation is required to validate this methodology, which could greatly improve identification of patients with skeletal fragility.
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