ArticleEuropean child & adolescent psychiatry2024
Functional brain network alterations in the co-occurrence of autism spectrum disorder and attention deficit hyperactivity disorder.
Article in European child & adolescent psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Altered Glymphatic-Related MRI Metrics and Brain Network Reorganization in Drug-Naive Children With Self-Limited Epilepsy With Centrotemporal Spikes.CNS neuroscience & therapeutics · 2026Article
- Functional brain growth trajectories across the first decade of life from a single longitudinal cohort.Research square · 2026Article
- Article
- Atypical development of white matter structural networks in children and adolescents with autism spectrum disorder: a graph theory study.Frontiers in neuroscience · 2026Article
- Overlapping and distinct intrinsic connectivity of hippocampal and triple networks in autistic individuals with and without a comorbid condition of ADHD.Frontiers in psychiatry · 2026Article
- Functional connectivity patterns differ as a function of co-occurring attentional problems in preschoolers with autism.Journal of neurodevelopmental disorders · 2025Article
- The histone methyltransferase SETD2 regulates adult brain structure, connectivity and neurogenesis.Scientific reports · 2025Article
- Sex Differences in Functional Gradients and Dynamic Functional Connectivity in Preschool-Aged Children With ASD.CNS neuroscience & therapeutics · 2025Article
- Developmental functional brain network abnormalities in autism spectrum disorder comorbid with attention deficit hyperactivity disorder.European journal of pediatrics · 2025Article
- ASD-SWNet: a novel shared-weight feature extraction and classification network for autism spectrum disorder diagnosis.Scientific reports · 2024Article
- Spatial-Temporal Characteristics of Brain Activity in Autism Spectrum Disorder Based on Hidden Markov Model and Dynamic Graph Theory: A Resting-State fMRI Study.Brain sciences · 2024Article
- Early diagnosis of autism spectrum disorder using structural connectivity biomarker.Psychoradiology · 2024Article
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Authors and funding
12 authors.
Funding
Abstract
Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are two highly prevalent and commonly co-occurring neurodevelopmental disorders. The neural mechanisms underpinning the comorbidity of ASD and ADHD (ASD + ADHD) remain unclear. We focused on the topological organization and functional connectivity of brain networks in ASD + ADHD patients versus ASD patients without ADHD (ASD-only). Resting-state functional magnetic resonance imaging (rs-fMRI) data from 114 ASD and 161 typically developing (TD) individuals were obtained from the Autism Brain Imaging Data Exchange II. The ASD patients comprised 40 ASD + ADHD and 74 ASD-only individuals. We constructed functional brain networks for each group and performed graph-theory and network-based statistic (NBS) analyses. Group differences between ASD + ADHD and ASD-only were analyzed at three levels: nodal, global, and connectivity. At the nodal level, ASD + ADHD exhibited topological disorganization in the temporal and occipital regions, compared with ASD-only. At the global level, ASD + ADHD and ASD-only displayed no significant differences. At the connectivity level, the NBS analysis revealed that ASD + ADHD showed enhanced functional connectivity between the prefrontal and frontoparietal regions, as well as between the orbitofrontal and occipital regions, compared with ASD-only. The hippocampus was the shared region in aberrant functional connectivity patterns in ASD + ADHD and ASD-only compared with TD. These findings suggests that ASD + ADHD displays altered topology and functional connectivity in the brain regions that undertake social cognition, language processing, and sensory processing.
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