ReviewArchives of toxicology2023
Mammalian toxicity of trifluoroacetate and assessment of human health risks due to environmental exposures.
Review in Archives of toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Derivation of guidance values under the EU Drinking Water Directive : the case study of trifluoroacetic acid.Archives of toxicology · 2026Review
- Trifluoroacetate mediated reduction of atherosclerosis in mice.Nature communications · 2026Article
- Tumor-Responsive Delivery of 5-Fluorouracil from a Redox-Triggered Supramolecular Gelator.Bioconjugate chemistry · 2026Article
- Scientific Report on consumer health-based guidance values for trifluoroacetic acid.EFSA journal. European Food Safety Authority · 2026Article
- Hormone-Driven Growth Signaling as a Therapeutic Target in Acute Myeloid Leukemia: Implications for Drug-Resistant Disease.Journal of personalized medicine · 2026Review
- Review
- Aromatic Ester Bioplastics from Wood and Cellulose: Cinnamates as Greener Alternatives to Benzoates.Materials (Basel, Switzerland) · 2026Article
- The Hydration of Trifluoroacetic Acid from 0 to 298 K.The journal of physical chemistry. A · 2026Article
- The Effects of Trifluoroacetic Acid (TFA) in Humans: A Rapid Review.Life (Basel, Switzerland) · 2025Review
- Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma.Science advances · 2025Article
- Thermal treatment of hexafluoropropylene oxide dimer acid (HFPO-DA) using a pilot-scale research combustor.Journal of hazardous materials · 2025Article
- Towards a Consensus for the Analysis and Exchange of TFA as a Counterion in Synthetic Peptides and Its Influence on Membrane Permeation.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Tiny molecules, big concerns: ultrashort-chain PFAS on the regulatory radar.Archives of toxicology · 2025Article
- Nanoscale fletching of liquid-like polydimethylsiloxane with single perfluorocarbons enables sustainable oil-repellency.Nature communications · 2025Article
- Trifluoroacetic Acid: An Ultra-Short PFAS with Emerging Environmental and Public Health Concerns.ACS ES&T water · 2025Article
- Article
- Derivation of Provisional Drinking Water Tolerance Values for Several PFAS Not Included in the Austrian Drinking Water Regulation.Food risk assess Europe · 2025Article
- Environmental consequences of interacting effects of changes in stratospheric ozone, ultraviolet radiation, and climate: UNEP Environmental Effects Assessment Panel, Update 2024.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025Article
- The Global Threat from the Irreversible Accumulation of Trifluoroacetic Acid (TFA).Environmental science & technology · 2024Review
- Base-free trifluoroacetylation: From methyl glucopyranoside to cellulose nanofibers.Carbohydrate research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While trifluoroacetic acid has limited technical uses, the highly water-soluble trifluoroacetate (TFA) is reported to be present in water bodies at low concentrations. Most of the TFA in the environment is discussed to arise from natural processes, but also with the contribution from decomposition of environmental chemicals. The presence of TFA may result in human exposures. For hazard and risk assessment, the mammalian toxicity of TFA and human exposures are reviewed to assess the margin of exposures (MoE). The potential of TFA to induce acute toxicity is very low and oral repeated dose studies in rats have identified the liver as the target organ with mild liver hypertrophy as the lead effect. Biomarker analyses indicate that TFA is a weak peroxisome proliferator in rats. TFA administered to rats did not induce adverse effects in an extended one-generation study and in a developmental toxicity study or induce genotoxic responses. Based on recent levels of TFA in water and diet, MoEs for human exposures to TFA are well above 100 and do not indicate health risks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.