Evidence map›Paper›PMID 36799997›Full record

ArticleAbdominal radiology (New York)2023

Longitudinal changes in quantitative magnetic resonance imaging metrics in children and young adults with autoimmune liver disease.

Neeraja Mahalingam, Andrew T Trout, Bin Zhang, Cyd Castro-Rojas, Alexander G Miethke, Jonathan R Dillman

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Abdominal radiology (New York), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03175471 (Cross-sectional Study for Assessment of MRI Based Biomarkers of Bile Duct Injury and Hepatic Fibrosis in Pediatric Onset Autoimmune Liver Disease), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03175471 recruitingnot on this map

Cross-sectional Study for Assessment of MRI Based Biomarkers of Bile Duct Injury and Hepatic Fibrosis in Pediatric Onset Autoimmune Liver Disease

TypeobservationalSponsorChildren's Hospital Medical Center, CincinnatiRan2017 to 2030Enrolled115ConditionsAutoimmune Liver Disease, Primary Sclerosing Cholangitis, Autoimmune Hepatitis
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Neeraja MahalingamDepartment of Radiology, Cincinnati Children's Hospital Medical Center, 250 Albert Sabin Way, Cincinnati, OH, 45229, USA. Neeraja.Mahalingam@cchmc.org.
Andrew T TroutDepartment of Radiology, Cincinnati Children's Hospital Medical Center, 250 Albert Sabin Way, Cincinnati, OH, 45229, USA.
Bin ZhangDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Cyd Castro-RojasDivision of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Alexander G MiethkeDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Jonathan R DillmanDepartment of Radiology, Cincinnati Children's Hospital Medical Center, 250 Albert Sabin Way, Cincinnati, OH, 45229, USA.ORCID http://orcid.org/0000-0003-0124-0164
Cincinnati Children's Hospital Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess longitudinal changes in quantitative MRI metrics in pediatric and young adult patients with autoimmune liver disease (AILD).

methodsThis prospective, IRB-approved study included 20 children and young adults (median age = 15 years) with primary sclerosing cholangitis (PSC)/autoimmune sclerosing cholangitis (ASC) and 19 (median age = 17 years) with autoimmune hepatitis (AIH). At a field strength of 1.5-T, T2*-corrected T1 mapping (cT1), 3D fast spin-echo MRCP, and 2D gradient recalled echo MR elastography (MRE) were performed at baseline, one year, and two years. cT1 and quantitative MRCP were processed using LiverMultiScan and MRCP + , respectively (Perspectum Ltd, Oxford, UK). Linear mixed models were used to assess longitudinal changes in quantitative MRI metrics. Spearman rank-order correlation was used to assess relationships between changes in quantitative MRI metrics.

resultsChanges in quantitative MRI metrics greater than established repeatability coefficients were measured in six (cT1) and five (MRE) patients with PSC/ASC as well as in six patients (cT1 and MRE) with AIH, although linear mixed models identified no significant changes for the subgroups as a whole. For PSC/ASC, there were positive correlations between change in liver stiffness and changes in bile duct strictures (ρ = 0.68; p = 0.005) and bile duct dilations (ρ = 0.70; p = 0.004) between baseline and Year 2.

conclusionOn average, there were no significant changes in quantitative MRI metrics over a two-year period in children and young adults with AILD. However, worsening cholangiopathy was associated with increasing liver stiffness by MRE in patients with PSC/ASC.

Indexed as

Cholangitis, SclerosingElasticity Imaging TechniquesHepatitis, AutoimmuneAdolescentBile DuctsChildHumansMagnetic Resonance ImagingProspective StudiesYoung AdultAutoimmune liver diseaseChildrenLongitudinal assessmentMagnetic resonance cholangiopancreatography (MRCP)MR elastographyQuantitative magnetic resonance imagingT1 mapping

Identifiers

PMID36799997
OpenAlexW4321165896

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.