ArticleInternational journal of legal medicine2023
PMI estimation through metabolomics and potassium analysis on animal vitreous humour.
Article in International journal of legal medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Advances in postmortem interval estimation: A systematic review of machine learning and metabolomics across various tissue types.Forensic science, medicine, and pathology · 2025Pooled it
- microRNAs as New Biomolecular Markers to Estimate Time since Death: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Potential Role of mRNA in Estimating Postmortem Interval: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Postmortem metabolomics as a window into the agonal phase of death: a comparison between opioid intoxications and hangings.International journal of legal medicine · 2026Article
- Special Issue "Advances in Molecular Forensic Pathology and Toxicology: An Update".International journal of molecular sciences · 2026Article
- A Step Forward in Post-Mortem Interval Estimation: Multivariate Analysis of Ammonium, Albumin, and Potassium Levels in Vitreous Humor.Diagnostics (Basel, Switzerland) · 2026Article
- Human-to-Rat Validation of PMI Biomarkers: A Bidirectional Cross-Species Metabolomics Study Reveals Asymmetric Translation.Analytical chemistry · 2026Article
- Metallomic Analysis of Vitreous Humor of the Human Eye-A Post-Mortem Multielemental Study.International journal of molecular sciences · 2026Article
- The human metabolome and machine learning improves predictions of the post-mortem interval.Nature communications · 2026Article
- Molecular biology research progress in post-mortem interval (PMI) estimation in forensic medicine.International journal of legal medicine · 2026Review
- Article
- PMI estimation throughMetabolomics : Official journal of the Metabolomic Society · 2025Article
- Amino acids and their metabolites as potential biochemical markers in postmortem vitreous humour.International journal of legal medicine · 2025Article
- Estimation of postmortem interval under different ambient temperatures based on multi-organ metabolomics and machine learning algorithm.International journal of legal medicine · 2025Article
- Translating metabolomic evidence gathered from an animal model to a real human scenario: the post-mortem interval issue.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Article
- Postmortem biochemistry of GFAP, NSE and S100B in cerebrospinal fluid and in vitreous humor for estimation of postmortem interval: a pilot study.Forensic science, medicine, and pathology · 2025Article
- UPLC/Q-TOF MS-based femoral muscle metabolomic analysis under high-temperature: a proof of concept for postmortem interval estimation.Frontiers in medicine · 2025Article
- Postmortem metabolomics as a high-throughput cause-of-death screening tool for human death investigations.iScience · 2024Article
- Volabolomic Fingerprinting for Post-Mortem Interval Estimation: A Novel Physiological Approach.Biomolecules · 2024Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe estimation of post-mortem interval (PMI) remains a major challenge in forensic science. Most of the proposed approaches lack the reliability required to meet the rigorous forensic standards.
objectivesWe applied
methodsVitreous humour samples were collected in a time frame ranging from 6 to 86 h after death. Experiments were performed by using
resultsA multivariate calibration model was built to estimate PMI based on 47 vitreous humour samples. The model was validated with an independent test set of 24 samples, obtaining a prediction error on the entire range of 6.9 h for PMI < 24 h, 7.4 h for PMI between 24 and 48 h, and 10.3 h for PMI > 48 h. Time-related modifications of the
conclusionThe present study, although in a proof-of-concept animal model, shows that vitreous metabolomics can be a powerful tool to predict PMI providing a more accurate estimation compared to the widely studied approach based on vitreous potassium concentrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.