Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
19 authors at 5 institutions in 2 countries.
Alix TrösterCenter for Biomolecular Magnetic Resonance Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany.
Michael DiPrimaLaboratory of Cellular Oncology Center for Cancer Research (CCR), National Cancer Institute (NCI), 37 Convent Drive, NIH Bethesda Campus Building 37, Room 4124, Bethesda, MD 20892, USA.ORCID http://orcid.org/0000-0001-9189-6049
Nathalie JoresCenter for Biomolecular Magnetic Resonance Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0002-8973-1648
Denis KudlinzkiCenter for Biomolecular Magnetic Resonance Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0002-8312-4388
Sridhar SreeramuluCenter for Biomolecular Magnetic Resonance Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0003-4509-4568
Santosh L GandeCenter for Biomolecular Magnetic Resonance Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany.
Verena LinhardCenter for Biomolecular Magnetic Resonance Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0002-0278-9792
Damian LudigCenter for Biomolecular Magnetic Resonance Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0002-0042-6322
Alexander SchugCenter for Biomolecular Magnetic Resonance Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany.
Krishna SaxenaCenter for Biomolecular Magnetic Resonance Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0002-2237-5378
Maria ReineckeChair of Proteomics and Bioanalytics, Technical University of Munich, Emil-Erlenmeyer-Forum 5, 85354, Freising, Germany.ORCID http://orcid.org/0000-0002-1008-408X
Stephanie HeinzlmeirChair of Proteomics and Bioanalytics, Technical University of Munich, Emil-Erlenmeyer-Forum 5, 85354, Freising, Germany.ORCID http://orcid.org/0000-0002-1066-6565
Matthias S LeisegangInstitute for Cardiovascular Physiology, Johann Wolfgang Goethe-University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0002-6084-6484
Bernhard KusterChair of Proteomics and Bioanalytics, Technical University of Munich, Emil-Erlenmeyer-Forum 5, 85354, Freising, Germany.ORCID http://orcid.org/0000-0002-9094-1677
Giovanna TosatoLaboratory of Cellular Oncology Center for Cancer Research (CCR), National Cancer Institute (NCI), 37 Convent Drive, NIH Bethesda Campus Building 37, Room 4124, Bethesda, MD 20892, USA.ORCID http://orcid.org/0000-0003-1663-3227
Harald SchwalbeCenter for Biomolecular Magnetic Resonance Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max-von-Laue-Straße 7, 60438, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0001-5693-7909
Goethe University Frankfurt · DEHelmholtz-Zentrum Berlin für Materialien und Energie · DEGerman Cancer Research Center · DENational Cancer Institute · USTechnical University of Munich · DE
Funding
Angiogenesis and Tumor GrowthZIASC010355 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI TOSATO, GIOVANNA · 2009 to 2025
$13.3M
Study of the Roles of SDF1 and CXCR4 in HematopoiesisZIABC010782 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TOSATO, GIOVANNA · 2009 to 2025
$10.2M
Intramural NIH HHS ZIA SC010355
6 · The paper itself
Abstract
The ephrin type-A receptor 2 (EPHA2) kinase belongs to the largest family of receptor tyrosine kinases. There are several indications of an involvement of EPHA2 in the development of infectious diseases and cancer. Despite pharmacological potential, EPHA2 is an under-examined target protein. In this study, we synthesized a series of derivatives of the inhibitor NVP-BHG712 and triazine-based compounds. These compounds were evaluated to determine their potential as kinase inhibitors of EPHA2, including elucidation of their binding mode (X-ray crystallography), affinity (microscale thermophoresis), and selectivity (Kinobeads assay). Eight inhibitors showed affinities in the low-nanomolar regime (K
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Optimization of the Lead Compound NVP-BHG712 as a Colorectal Cancer Inhibitor. · full record | OpenQuestion