ReviewCancer medicine2023
Dose-volume constraints for head-and-neck cancer in carbon ion radiotherapy: A literature review.
Review in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Effect of Carbon-Ion Radiation Therapy on Maxillary Ameloblastic Fibrosarcoma.Advances in radiation oncology · 2026Article
- Factors requiring adaptive re-planning in carbon ion radiotherapy for head and neck cancers.Frontiers in oncology · 2026Article
- Integrating dose-volume histogram parameters and radiomics-based machine learning to identify carbon ion radiotherapy-induced acute oral mucositis in patients with head and neck cancer.Physics and imaging in radiation oncology · 2025Article
- Dose Constraints in Carbon-Ion Radiation Therapy to Minimize the Risk of Pectoral Myositis.International journal of particle therapy · 2025Article
- Impact of perineural tumor spread in head and neck adenoid cystic carcinoma for carbon-ion radiotherapy.Clinical and translational radiation oncology · 2025Article
- Dose-Volume Constraints for Thoracic, Abdominal, and Pelvic Carbon Ion Radiotherapy: A Literature Review.Cancer medicine · 2025Review
- Dose-volume constraints for head-and-neck cancer in carbon ion radiotherapy: A literature review.Cancer medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCarbon ion radiotherapy (CIRT) has been applied in cancer treatment for over 25 years. However, guidelines for dose-volume constraints have not been established yet. The aim of this review is to summarize the dose-volume constraints in CIRT for head-and-neck (HN) cancer that were determined through previous clinical studies based on the Japanese models for relative biological effectiveness (RBE).
methodsA literature review was conducted to identify all constraints determined for HN cancer CIRT that are based on the Japanese RBE models.
resultsDose-volume constraints are reported for 17 organs at risk (OARs), including the brainstem, ocular structures, masticatory muscles, and skin. Various treatment planning strategies are also presented for reducing the dose delivered to OARs.
conclusionsThe reported constraints will provide assistance during treatment planning to ensure that radiation to OARs is minimized, and thus adverse effects are reduced. Although the constraints are given based on the Japanese RBE models, applying the necessary conversion factors will potentially enable their application by institutions worldwide that use the local effect model for RBE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.