Evidence map›Paper›PMID 36798939›Full record

ArticleProceedings of SPIE--the International Society for Optical Engineering

Thyroid Carcinoma Detection on Whole Histologic Slides Using Hyperspectral Imaging and Deep Learning.

Minh Ha Tran, Ling Ma, James V Litter, Amy Y Chen, Baowei Fei

Abstract read
In one paragraph

Article in Proceedings of SPIE--the International Society for Optical Engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Optimization of Transfer Learning of Foundation Models for Hyperspectral Histologic Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2025
    Article
  5. A high-speed hyperspectral imaging system and large-scale hyperspectral dataset for abdominal surgical applications.Proceedings of SPIE--the International Society for Optical Engineering · 2025
    Article
  6. An automatic processing framework for hyperspectral histologic images and benchmark dataset.Proceedings of SPIE--the International Society for Optical Engineering · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. A Video Transformer Network for Thyroid Cancer Detection on Hyperspectral Histologic Images.Proceedings of SPIE--the International Society for Optical Engineering · 2023
    Article
  12. Extended Depth of Field Imaging for Mosaic Hyperspectral Images.Proceedings of SPIE--the International Society for Optical Engineering · 2023
    Article
  13. Article
  14. Trends in AI-powered Classification of Thyroid Neoplasms Based on Histopathology Images - a Systematic Review.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2023
    Article
  15. Article
  16. An automatic whole-slide hyperspectral imaging microscope.Proceedings of SPIE--the International Society for Optical Engineering
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Minh Ha TranUniv. of Texas at Dallas, Dept. of Bioengineering, Richardson, TX.
Ling MaUniv. of Texas at Dallas, Dept. of Bioengineering, Richardson, TX.
James V LitterEmory Univ. School of Medicine, Dept. of Pathology and Laboratory Medicine, Atlanta, GA.
Amy Y ChenEmory Univ. School of Medicine, Dept. of Otolaryngology, Atlanta, GA.
Baowei FeiUniv. of Texas at Dallas, Dept. of Bioengineering, Richardson, TX.

Funding

Image-guided Intravascular Robotic System for Mitral Valve Repair and ImplantsR01HL140325 · NHLBI · GEORGIA INSTITUTE OF TECHNOLOGY · PI DESAI, JAYDEV P., FEI, BAOWEI · 2018 to 2021
$3.0M
ACADEMIC-INDUSTRIAL PARTNERSHIP FOR TRANSLATION OF PET/TRUS GUIDED INTERVENTIONR01CA204254 · NCI · UNIVERSITY OF TEXAS DALLAS · PI FEI, BAOWEI · 2017 to 2021
$2.0M
MOLECULAR IMAGING DIRECTED, 3D ULTRASOUND-GUIDED, BIOPSY SYSTEMR01CA156775 · NCI · UNIVERSITY OF TEXAS DALLAS · PI FEI, BAOWEI · 2011 to 2016
$1.7M
STAN-CT: Standardization and Normalization of CT images for Lung Cancer PatientsR21CA231911 · NCI · UNIVERSITY OF KENTUCKY · PI CHEN, JIN, FEI, BAOWEI · 2019 to 2020
$389k
NCI NIH HHS R01 CA156775NCI NIH HHS R01 CA204254NCI NIH HHS R21 CA231911NHLBI NIH HHS R01 HL140325
6 · The paper itself

Abstract

Hyperspectral imaging (HSI), a non-invasive imaging modality, has been successfully used in many different biological and medical applications. One such application is in the field of oncology, where hyperspectral imaging is being used on histologic samples. This study compares the performances of different image classifiers using different imaging modalities as training data. From a database of 33 fixed tissues from head and neck patients with follicular thyroid carcinoma, we produced three different datasets: an RGB image dataset that was acquired from a whole slide image scanner, a hyperspectral (HS) dataset that was acquired with a compact hyperspectral camera, and an HS-synthesized RGB image dataset. Three separate deep learning classifiers were trained using the three datasets. We show that the deep learning classifier trained on HSI data has an area under the receiver operator characteristic curve (AUC-ROC) of 0.966, higher than that of the classifiers trained on RGB and HSI-synthesized RGB data. This study demonstrates that hyperspectral images improve the performance of cancer classification on whole histologic slides. Hyperspectral imaging and deep learning provide an automatic tool for thyroid cancer detection on whole histologic slides.

Indexed as

deep learningdigital pathologyHyperspectral imagingthyroid cancerwhole-slide histologic imaging

Identifiers

PMID36798939
PMCPMC9929647

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.