Evidence map›Paper›PMID 36798799›Full record

ArticleOrthopaedic journal of sports medicine2023

The Use of Biologics in NFL Athletes: An Expert Consensus of NFL Team Physicians.

Iain R Murray, Timothy R McAdams, Kyle E Hammond, Fares S Haddad, Scott A Rodeo, Geoffrey D Abrams, a Group of American Professional Football Physicians, Larry Bankston, Asheesh Bedi, Martin Boublik and 16 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Orthopaedic journal of sports medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 1 institution in 1 country.

Iain R MurrayInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
Timothy R McAdamsInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
Kyle E HammondInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
Fares S HaddadInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
Scott A RodeoInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
Geoffrey D AbramsInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
a Group of American Professional Football Physicians
Larry BankstonInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
Asheesh BediInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
Martin BoublikInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
Mark BowenInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
James P BradleyInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
Dan E CooperInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
Charles CraythorneInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
Leigh-Ann CurlInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
Neal ElAttracheInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
David S GazzanigaInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
Kevin KaplanInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
Elias Edward KhalfayanInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
Christopher LarsonInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
Matthew PepeInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
Mark D PriceInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
J Paul SchroeppelInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
James VoosInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
Gary WaslewskiInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
Robin WestInvestigation performed at the Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
Stanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: There is a lack of published information outlining the use of biologics in National Football League (NFL) athletes and limited data to guide biologic treatment strategies. Purpose: To develop a consensus on the use of biologics among NFL team physicians. Study Design: Consensus statement. Methods: A working group of 6 experts convened a consensus process involving NFL team physicians using validated Delphi methodology. Physicians from 32 NFL teams as well as NFL London were invited to take part. This iterative process was used to define statements on the use of biologics in NFL athletes. A recent scoping review exploring biologics in professional athletes was used to inform the first of 3 rounds of surveys, with statements considered under 7 headings: biologics in general, challenges of treating NFL athletes, terminology/nomenclature, autologous blood products, cell-based therapies, guidance for NFL team physicians, and biologic research in the NFL. In addition to rating agreement, experts were encouraged to propose further items or modifications. Predefined criteria were used to refine item lists after each survey. For a consensus within the final round, defined a priori, items were included in the final information set if a minimum of 75% of respondents agreed and fewer than 10% disagreed. Results: Physicians from 26 NFL teams and NFL London responded to the initial invitation to participate in the Delphi process; 88.9% of participating team physicians completed the round 1 survey, with response rates of 87.5% in round 2 and 95.2% in round 3. After 3 rounds, 47 statements reached a consensus. A consensus was achieved that platelet-rich plasma has a positive impact on patellar tendinopathy and on symptoms in early osteoarthritis but not for other indications. NFL team physicians agreed that while cell therapies have the potential to improve symptoms, the misrepresentation of uncharacterized preparations as "stem cells" has contributed to the widespread use of unproven therapies. Conclusion: This study established an expert consensus on 47 statements relating to the use of biologics in NFL athletes. In addition to providing clinical guidance for the use of biologics in NFL athletes, this study identified key areas for future focus including the development of athlete education materials.

Indexed as

American footballbiologicsbone marrow aspirate concentrateplatelet-rich plasmastromal cells

Identifiers

PMID36798799
PMCPMC9926009
OpenAlexW4319940249

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.