Evidence map›Paper›PMID 36798608›Full record

ArticleNeuroscience insights2023

The Emerging Role of Biological Sex in Cell Therapy for Spinal Cord Injury.

Ashley Tucker, Jennifer N Dulin

Abstract read
In one paragraph

Article in Neuroscience insights, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ashley TuckerDepartment of Biology, Texas A&M University, College Station, TX, USA.
Jennifer N DulinDepartment of Biology, Texas A&M University, College Station, TX, USA.ORCID https://orcid.org/0000-0001-5767-4290

Funding

Dissecting Connectivity and Function of Transplanted Interneurons in the Injured Spinal CordR01NS116404 · NINDS · TEXAS A&M UNIVERSITY · PI DULIN, JENNIFER N · 2021 to 2025
$1.8M
NINDS NIH HHS R01 NS116404
6 · The paper itself

Abstract

Neural progenitor cell (NPC) transplantation is a promising potential therapy for replacing spinal cord neurons and glial cells following spinal cord injury (SCI). Despite the rapid advancement of NPC transplantation to SCI clinical trials, we still lack understanding of fundamental biology underlying how NPC grafts interact with the injured host nervous system. Our recent study demonstrated a potent effect of biological sex mismatch between donor and host on graft immune rejection. Here we discuss the implications of this study in the context of clinical trials for SCI, and important topics for future research in SCI cell transplantation.

Indexed as

clinical trialsgraft rejectionNeural progenitor cell transplantationsex mismatch

Identifiers

PMID36798608
PMCPMC9925999

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.