Evidence map›Paper›PMID 36798457›Full record

ArticleArXiv2023

The Effects of leaflet material properties on the simulated function of regurgitant mitral valves.

Wensi Wu, Stephen Ching, Patricia Sabin, Devin W Laurence, Steve A Maas, Andras Lasso, Jeffrey A Weiss, Matthew A Jolley

Abstract readPreprint
PubMed Full text at PMC
In one paragraph

Article in ArXiv, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Wensi WuDepartment of Anesthesiology and Critical Care Medicine, Division of Pediatric Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Stephen ChingDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Patricia SabinDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Devin W LaurenceDepartment of Anesthesiology and Critical Care Medicine, Division of Pediatric Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Steve A MaasDepartment of Biomedical Engineering, and Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT 84112.
Andras LassoLaboratory for Percutaneous Surgery, Queen's University, Kingston, ON.
Jeffrey A WeissDepartment of Biomedical Engineering, and Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT 84112.
Matthew A JolleyDepartment of Anesthesiology and Critical Care Medicine, Division of Pediatric Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104.

Funding

Training in Molecular Therapeutics for Pediatric CardiologyT32HL007915 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Robert J Levy, JOSEPH W ROSSANO · 1999 to 2026
$13.4M
Finite Elements For Biomechanics And BiophysicsR01GM083925 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI GERARD A. ATESHIAN, JEFFREY A. WEISS · 2008 to 2026
$7.6M
Computer Modeling of the Tricuspid Valve in Hypoplastic Left Heart SyndromeR01HL153166 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI JOLLEY, MATTHEW · 2020 to 2024
$3.7M
Lab-to-User Training and Dissemination for the FEBio Software SuiteU24EB029007 · NIBIB · UNIVERSITY OF UTAH · PI WEISS, JEFFREY A. · 2019 to 2023
$1.3M
NHLBI NIH HHS R01 HL153166NHLBI NIH HHS T32 HL007915NIBIB NIH HHS U24 EB029007NIGMS NIH HHS R01 GM083925
6 · The paper itself

Abstract

Advances in three-dimensional imaging provide the ability to construct and analyze finite element (FE) models to evaluate the biomechanical behavior and function of atrioventricular valves. However, while obtaining patient-specific valve geometry is now possible, non-invasive measurement of patient-specific leaflet material properties remains nearly impossible. Both valve geometry and tissue properties play a significant role in governing valve dynamics, leading to the central question of whether clinically relevant insights can be attained from FE analysis of atrioventricular valves without precise knowledge of tissue properties. As such we investigated 1) the influence of tissue extensibility and 2) the effects of constitutive model parameters and leaflet thickness on simulated valve function and mechanics. We compared metrics of valve function (

Indexed as

tissue propertiesuncertainty analysisvalve functionvalve mechanicsvalvular regurgitation

Identifiers

PMID36798457
PMCPMC9934730

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.