Evidence map›Paper›PMID 36798417›Full record

ArticlebioRxiv : the preprint server for biology2023

Ormdl3 regulation of specific ceramides is dispensable for β-cell function and glucose homeostasis under obesogenic conditions.

Liam D Hurley, Hugo Lee, Gina Wade, Judith Simcox, Feyza Engin

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

  • Updated by
    2023
5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Liam D HurleyDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI 53706, USA.
Hugo LeeDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI 53706, USA.
Gina WadeDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Judith SimcoxDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Feyza EnginDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI 53706, USA.
University of Wisconsin–Madison · US

Funding

GRADUATE TRAINING IN MOLECULAR BIOSCIENCEST32GM007215 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HULL, CHRISTINA M · 1985 to 2018
$22.5M
The role of beta cell ATF6 in type 1 diabetesR01DK130919 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Feyza Engin · 2021 to 2026
$2.7M
Discovery and characterization of a novel acylcarnitine transporter in brown adipocytesR01DK133479 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Judith Anne Simcox · 2022 to 2026
$1.5M
Metabolic basis of beta cell stress adaptationR56DK128136 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI ENGIN, FEYZA · 2021 to 2021
$194k
NIDDK NIH HHS R01 DK130919NIDDK NIH HHS R01 DK133479NIDDK NIH HHS R56 DK128136NIGMS NIH HHS T32 GM007215
6 · The paper itself

Abstract

Chronic elevation of sphingolipids contributes to β-cell failure. ORMDL3 has been identified as a key regulator of sphingolipid homeostasis, however, its function in pancreatic β-cell pathophysiology remains unclear. Here, we generated a mouse model lacking

Identifiers

PMID36798417
PMCPMC9934654
OpenAlexW4320183018

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.