Evidence map›Paper›PMID 36798375›Full record

ArticleResearch square2023

Engineered MED12 mutations drive uterine fibroid-like transcriptional and metabolic programs by altering the 3D genome compartmentalization.

Kadir Buyukcelebi, Xintong Chen, Fatih Abdula, Alexander Duval, Harun Ozturk, Fidan Seker-Polat, Qiushi Jin, Ping Yin, Yue Feng, Jian-Jun Wei and 3 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Kadir BuyukcelebiNorthwestern University.
Xintong ChenNorthwestern University.
Fatih AbdulaNorthwestern University.ORCID 0000-0002-2728-5160
Alexander DuvalNorthwestern University.
Harun OzturkNorthwestern University.
Fidan Seker-PolatNorthwestern University.
Qiushi JinNorthwestern University.
Ping YinNorthwestern University.
Yue FengNorthwestern University.
Jian-Jun WeiNorthwestern University.ORCID 0000-0003-0281-2793
Serdar BulunNorthwestern University.
Feng YueNorthwestern University.ORCID 0000-0002-7954-5462
Mazhar AdliNorthwestern University.

Funding

The Origin and Cellular Heterogeneity of Uterine LeiomyomasP50HD098580 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SIMON, MELISSA A. · 2019 to 2023
$7.4M
NICHD NIH HHS P50 HD098580
6 · The paper itself

Abstract

Uterine fibroid (UF) tumors originate from a mutated smooth muscle cell (SMC). Nearly 70% of these tumors are driven by hotspot recurrent somatic mutations in the

Identifiers

PMID36798375
PMCPMC9934745
OpenAlexW4319770272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.