Evidence map›Paper›PMID 36798372›Full record

ArticleResearch square2023

A non-canonical striatopallidal "Go" pathway that supports motor control.

Marie A Labouesse, Arturo Torres-Herraez, Muhammad O Chohan, Joseph Villarin, Julia Greenwald, Xiaoxiao Sun, Mysarah Zahran, Alice Tang, Sherry Lam, Jeremy Veenstra-VanderWeele and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Marie A LabouesseDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-6850-5852
Arturo Torres-HerraezDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Muhammad O ChohanDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-9359-3700
Joseph VillarinDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Julia GreenwaldDivision of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA.
Xiaoxiao SunDivision of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA.
Mysarah ZahranDivision of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA.
Alice TangColumbia College, Columbia University, New York, NY 10027, USA.
Sherry LamBiobehavioral Imaging and Molecular Neuropsychopharmacology Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA.
Jeremy Veenstra-VanderWeeleDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Clay LacefieldDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.ORCID 0000-0001-5721-434X
Jordi BonaventuraBiobehavioral Imaging and Molecular Neuropsychopharmacology Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA.ORCID 0000-0002-4745-0151
Michael MichaelidesBiobehavioral Imaging and Molecular Neuropsychopharmacology Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA.ORCID 0000-0003-0398-4917
C Savio ChanDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-3474-1718
Ofer YizharDepartments of Brain Sciences and Molecular Neuroscience, Weizmann Institute of Science, Rehovot 76100, Israel.ORCID 0000-0003-4228-1448
Christoph KellendonkDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.ORCID 0000-0003-3302-2188

Funding

Training in Schizophrenia and Psychotic Disorders: From Animal Models to PatientsT32MH018870 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Guillermo Horga, Christoph Kellendonk · 1988 to 2026
$9.8M
Medium Spiny Neuron Excitability and MotivationR01MH093672 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI KELLENDONK, CHRISTOPH · 2011 to 2020
$5.0M
PRIMING THE PUMP: TRAINING PHYSICIAN-SCIENTISTS IN TRANSLATIONAL PSYCHIATRYR25MH086466 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Melissa Arbuckle, Eduardo David Leonardo · 2009 to 2026
$4.3M
Striatopallidal GABAergic Signaling in Mouse Models of Parkinson's DiseaseR01NS069777 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHAN, SAVIO · 2010 to 2021
$3.9M
Co-Regulation of Striatal Dopamine and Acetylcholine During Flexible LearningR01MH124858 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI KELLENDONK, CHRISTOPH · 2021 to 2025
$2.7M
Investigation of Pallidal Neurons in Motor InhibitionR56NS069777 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHAN, SAVIO · 2022 to 2022
$536k
NIMH NIH HHS R01 MH093672NIMH NIH HHS R01 MH124858NIMH NIH HHS R25 MH086466NIMH NIH HHS T32 MH018870NINDS NIH HHS R01 NS069777NINDS NIH HHS R56 NS069777
6 · The paper itself

Abstract

In the classical model of the basal ganglia, direct pathway striatal projection neurons (dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to regulate motor function. Recent studies have re-established that dSPNs also possess "bridging" collaterals within the globus pallidus (GPe), yet the significance of these collaterals for behavior is unknown. Here we use in vivo optical and chemogenetic tools combined with deep learning approaches to dissect the roles of bridging collaterals in motor function. We find that dSPNs projecting to the SNr send synchronous motor-related information to the GPe via axon collaterals. Inhibition of native activity in dSPN GPe terminals impairs motor activity and function via regulation of pallidostriatal Npas1 neurons. We propose a model by which dSPN GPe collaterals ("striatopallidal Go pathway") act in concert with the canonical terminals in the SNr to support motor control by inhibiting Npas1 signals going back to the striatum.

Indexed as

arkypallidalaxonal copyaxon collateralsbasal gangliabridging collateralsdirect pathwayefference copyglobus pallidusGo pathwaymedium spiny neuronsmotor controlNpas1striatopallidalstriatum

Identifiers

PMID36798372
PMCPMC9934763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.