Evidence map›Paper›PMID 36798364›Full record

ArticlebioRxiv : the preprint server for biology2023

Modulation of GPR133 (ADGRD1) Signaling by its Intracellular Interaction Partner Extended Synaptotagmin 1 (ESYT1).

Gabriele Stephan, Hediye Erdjument-Bromage, Wenke Liu, Joshua D Frenster, Niklas Ravn-Boess, Devin Bready, Julia Cai, David Fenyo, Thomas Neubert, Dimitris G Placantonakis

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Gabriele StephanDepartment of Neurosurgery, NYU Grossman School of Medicine, New York, NY 10016, USA.
Hediye Erdjument-BromageDepartment of Cell Biology and Kimmel Center for Biology and Medicine at the Skirball Institute, NYU Grossman School of Medicine, New York, NY 10016, USA.
Wenke LiuInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, NY 10016, USA.
Joshua D FrensterDepartment of Neurosurgery, NYU Grossman School of Medicine, New York, NY 10016, USA.
Niklas Ravn-BoessDepartment of Neurosurgery, NYU Grossman School of Medicine, New York, NY 10016, USA.
Devin BreadyDepartment of Neurosurgery, NYU Grossman School of Medicine, New York, NY 10016, USA.
Julia CaiDepartment of Neurosurgery, NYU Grossman School of Medicine, New York, NY 10016, USA.
David FenyoInstitute for Systems Genetics, NYU Grossman School of Medicine, New York, NY 10016, USA.
Thomas NeubertDepartment of Cell Biology and Kimmel Center for Biology and Medicine at the Skirball Institute, NYU Grossman School of Medicine, New York, NY 10016, USA.
Dimitris G PlacantonakisDepartment of Neurosurgery, NYU Grossman School of Medicine, New York, NY 10016, USA.
New York University · USInstitute for Systems Biology · USUniversitat Pompeu Fabra · ES

Funding

Project-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5M
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
Developmentally Regulated Enhancers and Chromatin Architecture in Human NeurogenesisR01NS124920 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Dimitris G. Placantonakis · 2022 to 2026
$2.7M
The role of GPR133 in glioblastomaR01NS102665 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PLACANTONAKIS, DIMITRIS G. · 2018 to 2022
$2.3M
Fingerprinting-Based Neuronal Fiber Identification in Brain SurgeryR01EB028774 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BAETE, STEVEN H. · 2020 to 2023
$1.9M
Calcium dynamics and signaling in gliomaR21NS126806 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PLACANTONAKIS, DIMITRIS G. · 2022 to 2022
$466k
Identification and molecular characterization of FGFR4 p.G388R variant signaling in cerebellar hemangioblastomasR21CA263402 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ZAGZAG, DAVID · 2021 to 2022
$431k
NCATS NIH HHS UL1 TR001445NCI NIH HHS P30 CA016087NCI NIH HHS R21 CA263402NIBIB NIH HHS R01 EB028774NINDS NIH HHS R01 NS102665NINDS NIH HHS R01 NS124920NINDS NIH HHS R21 NS126806
6 · The paper itself

Abstract

GPR133 (ADGRD1) is an adhesion G protein-coupled receptor that signals through Gαs and is required for growth of glioblastoma (GBM), an aggressive brain malignancy. The regulation of GPR133 signaling is incompletely understood. Here, we use proximity biotinylation proteomics to identify ESYT1, a Ca

Indexed as

adhesion G protein-coupled receptorcalciumcAMPESYT1extended synaptotagminGPR133

Identifiers

PMID36798364
PMCPMC9934660
OpenAlexW4319659052

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.