ArticlebioRxiv : the preprint server for biology2023
Mechanisms of spinophilin-dependent pancreas dysregulation underlying diabesity.
Kaitlyn C Stickel, Amber L Mosley, Emma H Doud, Teri L Belecky-Adams, Anthony J Baucum
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
5 authors at 3 institutions in 1 country.
Kaitlyn C StickelDepartment of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.
Amber L MosleyBiochemistry and Molecular Biology, Indiana University, Indianapolis, IN, USA.
Emma H DoudBiochemistry and Molecular Biology, Indiana University, Indianapolis, IN, USA.
Teri L Belecky-AdamsDepartment of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.
Anthony J BaucumDepartment of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.
University of Indianapolis · USIndiana University – Purdue University Indianapolis · USIndiana University School of Medicine
Funding
Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI David W Clapp · 1999 to 2026
$59.3MQuality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2MTranslation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4MSpinophilin function in regulating pathological responses to psychostimulant drugR33DA041876 · NIDA · INDIANA UNIVERSITY INDIANAPOLIS · PI BAUCUM, ANTHONY J. · 2018 to 2020
$1.2MTransforming Growth Factor Beta-Activated Kinase 1 (Tak1) in Retinal Microglial InflammationR15EY033968 · NEI · INDIANA UNIVERSITY INDIANAPOLIS · PI BELECKY-ADAMS, TERI L · 2022 to 2022
$456kGeneration of cell-specific tools to determine the role of spinophilin in regulating pathological responses to psychostimulant drugs of abuseR21DA041876 · NIDA · INDIANA UNIVERSITY INDIANAPOLIS · PI BAUCUM, ANTHONY J. · 2016 to 2017
$364kNCATS NIH HHS UL1 TR002529NCI NIH HHS P30 CA082709NEI NIH HHS R15 EY033968NIDA NIH HHS R21 DA041876NIDA NIH HHS R33 DA041876NIDDK NIH HHS P30 DK097512
6 · The paper itselfAbstract
Objective: Spinophilin is an F-actin binding and protein phosphatase 1 (PP1) targeting protein that acts as a scaffold of PP1 to its substrates. Spinophilin knockout (Spino Methods & Results: We have corroborated and expanded upon previous studies to determine that Spino Conclusion: Our data further support a role for spinophilin in mediating pathophysiological changes in body weight and whole-body metabolism associated with obesity and provide the first evidence that spinophilin mediates obesity-dependent pancreatic dysfunction that leads to deficits in glucose homeostasis or diabesity.
Indexed as
DiabesityObesityProtein Phosphatase 1Scaffolding ProteinsType 2 Diabetes
Identifiers
PMID36798361
PMCPMC9934546
OpenAlexW4319592954
What OpenQuestion holds
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LicenceCC BY-NC-ND
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