Evidence map›Paper›PMID 36798330›Full record

ArticlebioRxiv : the preprint server for biology2024

Target-specific requirements for RNA interference can arise through restricted RNA amplification despite the lack of specialized pathways.

Daphne R Knudsen-Palmer, Pravrutha Raman, Farida Ettefa, Laura De Ravin, Antony M Jose

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Daphne R Knudsen-PalmerDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, USA. Biological Sciences Graduate Program, University of Maryland, College Park, USA.ORCID 0000-0001-5745-1185
Pravrutha RamanDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, USA. Biological Sciences Graduate Program, University of Maryland, College Park, USA.ORCID 0000-0002-7435-9425
Farida EttefaDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, USA. Biological Sciences Graduate Program, University of Maryland, College Park, USA.ORCID 0000-0003-0433-5951
Laura De RavinDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, USA. Biological Sciences Graduate Program, University of Maryland, College Park, USA.
Antony M JoseDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, USA. Biological Sciences Graduate Program, University of Maryland, College Park, USA.ORCID 0000-0003-1405-0618
University of Maryland, College Park · USCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZANew York University · US

Funding

Transgenerational gene silencing by extracellular RNAR01GM124356 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI JOSE, ANTONY MERLIN · 2018 to 2025
$2.8M
Movement of RNA between animal cellsR01GM111457 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI JOSE, ANTONY MERLIN · 2014 to 2018
$1.4M
NIGMS NIH HHS R01 GM111457NIGMS NIH HHS R01 GM124356
6 · The paper itself

Abstract

Since double-stranded RNA (dsRNA) is effective for silencing a wide variety of genes, all genes are typically considered equivalent targets for such RNA interference (RNAi). Yet, loss of some regulators of RNAi in the nematode

Indexed as

epigeneticspUG RNAregulation of gene expressionRNA interference

Identifiers

PMID36798330
PMCPMC9934570
OpenAlexW4319592712

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.