Evidence map›Paper›PMID 36798319›Full record

ArticlebioRxiv : the preprint server for biology2023

Differential miRNA Expression Contributes to Emergence of Multiple Cancer Stem Cell Subpopulations in Human Colorectal Cancer.

Victoria A Stark, Caroline O B Facey, Lynn Opdenaker, Jeremy Z Fields, Bruce M Boman

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Victoria A StarkDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Caroline O B FaceyCenter for Translational Cancer Research, Helen F. Graham Cancer Center & Research Institute, Newark, DE 19713, USA.
Lynn OpdenakerDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Jeremy Z FieldsCATX Inc, Princeton NJ USA.
Bruce M BomanDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Center for Cancer Research · USThomas Jefferson University · US

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI MELINDA K DUNCAN · 2012 to 2026
$67.2M
NIGMS NIH HHS P20 GM103446
6 · The paper itself

Abstract

One reason for lack of efficacy in cancer therapeutics is tumor heterogeneity. We hypothesize that tumor heterogeneity arises due to emergence of multiple cancer stem cell (CSC) subpopulations because miRNAs regulate expression of stem cell genes in CSCs. Our goal was to determine if:

Indexed as

ALDHbiomarker(s)cancer stem cellsCD166colorectal cancerLGR5LRIG1microRNAstumor heterogeneity

Identifiers

PMID36798319
PMCPMC9934564
OpenAlexW4319299080

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.