Evidence map›Paper›PMID 36798317›Full record

ArticlebioRxiv : the preprint server for biology2023

Sangderk Lee, Holden C Williams, Amy A Gorman, Nicholas A Devanney, Douglas A Harrison, Adeline E Walsh, Danielle S Goulding, Tony Tuck, James L Schwartz, Diana J Zajac and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Sangderk LeeSanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY.
Holden C WilliamsSanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY.
Amy A GormanSanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY.
Nicholas A DevanneySanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY.
Douglas A HarrisonBoston University, Chobanian & Avedisian School of Medicine, Boston, MA.
Adeline E WalshDepartment of Biology, University of Kentucky College of Arts and Sciences, Lexington, KY.
Danielle S GouldingSanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY.
Tony TuckBoston University, Chobanian & Avedisian School of Medicine, Boston, MA.
James L SchwartzSanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY.
Diana J ZajacSanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY.
Shannon L MacauleyDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC.
Steven EstusSanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY.
Tcw JuliaBoston University, Chobanian & Avedisian School of Medicine, Boston, MA.
Lance A JohnsonSanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY.
Josh M MorgantiSanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY.
University of Kentucky · USBoston University · USWake Forest University · US

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Jennifer F Rogers · 2013 to 2026
$38.3M
Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI THOMAS COSTIN REGISTER · 2021 to 2026
$24.3M
Translating SHIP1 Genetics to Generate a Novel Alzheimers Pharmacologic AgentRF1AG059717 · NIA · UNIVERSITY OF KENTUCKY · PI ESTUS, STEVEN, HUMPHREY, MARY BETH · 2018 to 2019
$3.9M
The metabolic interplay of sleep and Alzheimer's diseaseR01AG068330 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MACAULEY-RAMBACH, SHANNON L · 2020 to 2024
$3.5M
Contributions of astrocyte RelA signaling in aging-related neurodegenerative sequelae following TBIR01AG070830 · NIA · UNIVERSITY OF KENTUCKY · PI MORGANTI, JOSH · 2021 to 2025
$3.3M
APOE Allele Switching as a Therapeutic Approach for Alzheimer's DiseaseR01AG080589 · NIA · UNIVERSITY OF KENTUCKY · PI Lance Allen Johnson · 2023 to 2026
$2.6M
APOE and the PPP: Glucose Metabolism and Oxidative Stress in Alzheimer's DiseaseR01AG060056 · NIA · UNIVERSITY OF KENTUCKY · PI JOHNSON, LANCE ALLEN · 2018 to 2022
$2.5M
Inflammatory contributions of astrocytic RelA in comorbid VCID/ADRF1NS118558 · NINDS · UNIVERSITY OF KENTUCKY · PI MORGANTI, JOSH · 2020 to 2021
$2.4M
Examining the Effects of the Neuroprotective APOE2 Allele on Peripheral ImmunometabolismR01AG062550 · NIA · UNIVERSITY OF KENTUCKY · PI JOHNSON, LANCE ALLEN · 2019 to 2023
$2.2M
Deciphering isogenic APOE isoform dependent neurodegenerative response in human gliaK01AG062683 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI TCW, JULIA · 2019 to 2023
$621k
Uncovering APOE4 Matrisome endophenotypes using human iPSC-based modelsR56AG078733 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TCW, JULIA · 2022 to 2022
$500k
How does D2-CD33 reduce Alzheimer's disease risk?R21AG068370 · NIA · UNIVERSITY OF KENTUCKY · PI ESTUS, STEVEN · 2020 to 2020
$421k
NCI NIH HHS P30 CA177558NIA NIH HHS K01 AG062683NIA NIH HHS P30 AG072947NIA NIH HHS R01 AG060056NIA NIH HHS R01 AG062550NIA NIH HHS R01 AG068330NIA NIH HHS R01 AG070830NIA NIH HHS R01 AG080589NIA NIH HHS R21 AG068370NIA NIH HHS R56 AG078733NIA NIH HHS RF1 AG059717NINDS NIH HHS RF1 NS118558
6 · The paper itself

Abstract

Apolipoprotein E4 (APOE4) is the strongest risk allele associated with the development of late onset Alzheimer's disease (AD). Across the CNS, astrocytes are the predominant expressor of

Identifiers

PMID36798317
PMCPMC9934552
OpenAlexW4319443176

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.