Evidence map›Paper›PMID 36798301›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Contributions of rare and common variation to early-onset and atypical dementia risk.

Carter A Wright, Jared W Taylor, Meagan Cochran, James M J Lawlor, Belle A Moyers, Michelle D Amaral, Zachary T Bonnstetter, Princess Carter, Veronika Solomon, Richard M Myers and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Carter A WrightHudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA.
Jared W TaylorHudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA.
Meagan CochranHudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA.
James M J LawlorHudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA.
Belle A MoyersHudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA.
Michelle D AmaralHudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA.
Zachary T BonnstetterHudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA.
Princess CarterAlzheimer's Disease Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Veronika SolomonAlzheimer's Disease Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Richard M MyersHudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA.
Marissa Natelson LoveAlzheimer's Disease Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
David S GeldmacherAlzheimer's Disease Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Sara J CooperHudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA.
Erik D RobersonAlzheimer's Disease Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
J Nicholas CochranHudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA.
University of Alabama at Birmingham · USHudsonAlpha Institute for Biotechnology · US

Funding

UAB Alzheimer's Disease Research CenterP20AG068024 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROBERSON, ERIK D · 2020 to 2022
$3.3M
Regulatory mechanisms of rare non-coding variation in neurodegeneration-associated lociR00AG068271 · NIA · HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY · PI COCHRAN, JESSE N · 2021 to 2023
$725k
NIA NIH HHS P20 AG068024NIA NIH HHS R00 AG068271
6 · The paper itself

Abstract

We collected and analyzed genomic sequencing data from individuals with clinician- diagnosed early-onset or atypical dementia. Thirty-two patients were previously described, with sixty-eight newly described in this report. Of those sixty-eight, sixty-two patients reported Caucasian, non-Hispanic ethnicity and six reported as African American, non-Hispanic. Fifty-three percent of patients had a returnable variant. Five patients harbored a pathogenic variant as defined by the American College of Medical Genetics criteria for pathogenicity. A polygenic risk score was calculated for Alzheimer's patients in the total cohort and compared to the scores of a late-onset Alzheimer's cohort and a control set. Patients with early-onset Alzheimer's had higher non-

Identifiers

PMID36798301
PMCPMC9934786
OpenAlexW4319459794

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.