Evidence map›Paper›PMID 36798296›Full record

ArticlebioRxiv : the preprint server for biology2023

Individual recombinant repeats of MUC16 display variable binding to CA125 antibodies.

Chien-Wei Wang, Eliza K Hanson, Lisa Minkoff, Rebecca J Whelan

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Chien-Wei WangDepartment of Chemistry, University of Kansas, Lawrence, KS, United States of America.
Eliza K HansonDepartment of Chemistry, University of Kansas, Lawrence, KS, United States of America.
Lisa MinkoffDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, United States of America.
Rebecca J WhelanDepartment of Chemistry, University of Kansas, Lawrence, KS, United States of America.
University of Notre Dame · US

Funding

Targeted proteomics of MUC16 to enable early detection of ovarian cancer recurrenceR21CA267532 · NCI · UNIVERSITY OF NOTRE DAME · PI WHELAN, REBECCA JEAN · 2022 to 2023
$412k
NCI NIH HHS R21 CA267532
6 · The paper itself

Abstract

backgroundDespite its importance in the clinical management of ovarian cancer, the CA125 biomarker-located on the mucin protein MUC16-is still not completely understood. Questions remain about MUC16's function and structure, specifically the identity and location of the CA125 epitopes.

objectiveThe goal of this study was to characterize the interaction of individual recombinant repeats from the tandem repeat domain of MUC16 with antibodies used in the clinical CA125 II test.

methodsUsing

resultsEach recombinant repeat was recognized by a different combination of CA125 antibodies. OC125 and "OC125-like" antibodies did not bind the same set of recombinant repeats, nor did M11 and "M11-like" antibodies.

conclusionsCharacterization of the interactions between MUC16 recombinant repeats and CA125 antibodies will contribute to ongoing efforts to identify the CA125 epitopes and improve our understanding of this important biomarker.

Identifiers

PMID36798296
PMCPMC9934600
OpenAlexW4319720213

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.