Evidence map›Paper›PMID 36798239›Full record

ArticlebioRxiv : the preprint server for biology2023

The BAF chromatin complex component SMARCC1 does not mediate GLI transcriptional repression of Hedgehog target genes in limb buds.

Janani Ramachandran, Wanlu Chen, Rachel K Lex, Kathryn E Windsor, Hyunji Lee, Tingchang Wang, Weiqiang Zhou, Hongkai Ji, Steven A Vokes

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Janani RamachandranDepartment of Molecular Biosciences, University of Texas at Austin, 100 E 24th Street Stop A5000, Austin, TX 78712 USA.
Wanlu ChenDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA.
Rachel K LexDepartment of Molecular Biosciences, University of Texas at Austin, 100 E 24th Street Stop A5000, Austin, TX 78712 USA.
Kathryn E WindsorDepartment of Molecular Biosciences, University of Texas at Austin, 100 E 24th Street Stop A5000, Austin, TX 78712 USA.
Hyunji LeeDepartment of Molecular Biosciences, University of Texas at Austin, 100 E 24th Street Stop A5000, Austin, TX 78712 USA.
Tingchang WangDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA.
Weiqiang ZhouDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA.
Hongkai JiDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA.
Steven A VokesDepartment of Molecular Biosciences, University of Texas at Austin, 100 E 24th Street Stop A5000, Austin, TX 78712 USA.
The University of Texas at Austin · USJohns Hopkins University · US

Funding

Cis-regulatory circuitry underlying Hedgehog mediated limb developmentR01HD073151 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI Steven Alexander Vokes · 2012 to 2026
$5.1M
Defining the epigenetic mechanisms underlying GLI-mediated transcriptional repressionF31DE027597 · NIDCR · UNIVERSITY OF TEXAS AT AUSTIN · PI LEX, RACHEL K · 2017 to 2020
$122k
NICHD NIH HHS R01 HD073151NIDCR NIH HHS F31 DE027597
6 · The paper itself

Abstract

Transcriptional responses to the Hedgehog (HH) signaling pathway are primarily modulated by GLI repression in the mouse limb. Previous studies suggested a role for the BAF chromatin remodeling complex in mediating GLI repression. Consistent with this possibility, the core BAF complex protein SMARCC1 is present at most active limb enhancers including the majority of GLI enhancers. However, in contrast to GLI repression which reduces chromatin accessibility, SMARCC1 maintains chromatin accessibility at most enhancers, including those bound by GLI. Moreover, SMARCC1 binding at GLI-regulated enhancers occurs independently of GLI3. Consistent with previous studies, some individual GLI target genes are mis-regulated in

Identifiers

PMID36798239
PMCPMC9934545
OpenAlexW4319460942

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.