Evidence map›Paper›PMID 36798200›Full record

ArticlebioRxiv : the preprint server for biology2023

P53 Acetylation Exerts Critical Roles In Pressure Overload Induced Coronary Microvascular Dysfunction and Heart Failure.

Xiaochen He, Aubrey C Cantrell, Quinesha A Williams, Wei Gu, Yingjie Chen, Jian-Xiong Chen, Heng Zeng

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xiaochen HeDepartment of Pharmacology & Toxicology, University of Mississippi Medical Center, School of Medicine, Jackson, MS, 39216, USA.
Aubrey C CantrellDepartment of Pharmacology & Toxicology, University of Mississippi Medical Center, School of Medicine, Jackson, MS, 39216, USA.
Quinesha A WilliamsDepartment of Pharmacology & Toxicology, University of Mississippi Medical Center, School of Medicine, Jackson, MS, 39216, USA.
Wei GuDepartment of Pathology & Cell Biology, Columbia University, Institute for Cancer Genetics, New York, NY 10032, USA.
Yingjie ChenDepartment of Physiology & Biophysics, University of Mississippi Medical Center, School of Medicine, Jackson, MS, 39216, USA.
Jian-Xiong ChenDepartment of Pharmacology & Toxicology, University of Mississippi Medical Center, School of Medicine, Jackson, MS, 39216, USA.
Heng ZengDepartment of Pharmacology & Toxicology, University of Mississippi Medical Center, School of Medicine, Jackson, MS, 39216, USA.
University of Mississippi Medical Center · USCancer Genetics (United States) · US

Funding

The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4M
Pilot Projects ProgramP30GM149404 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI DAVID E STEC · 2023 to 2026
$6.3M
Regulation of vascular maturation/regression in diabetesR01HL102042 · NHLBI · VANDERBILT UNIVERSITY · PI CHEN, JIAN-XIONG · 2010 to 2020
$3.0M
Endothelial PHD2 in hypertensive vascular remodelingR01HL151536 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CHEN, JIAN-XIONG · 2021 to 2024
$1.6M
P53 acetylation in microvascular rarefaction and heart failureR56HL164321 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI ZENG, HENG · 2022 to 2022
$388k
NHLBI NIH HHS R01 HL102042NHLBI NIH HHS R01 HL151536NHLBI NIH HHS R56 HL164321NIGMS NIH HHS P20 GM104357NIGMS NIH HHS P30 GM149404
6 · The paper itself

Abstract

Coronary microvascular dysfunction (CMD) has been shown to contribute to cardiac hypertrophy and heart failure with preserved ejection fraction. At this point, there are no proven treatments for CMD. We have shown that histone acetylation may play a critical role in the regulation of CMD. By using a mouse model that replaces lysine with arginine at residues K98/117/161/162R of p53 (p53

Indexed as

angiogenesiscardiac remodelingCFRheart failurep53 acetylation

Identifiers

PMID36798200
PMCPMC9934706
OpenAlexW4319724082

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.