Evidence map›Paper›PMID 36798187›Full record

ArticlebioRxiv : the preprint server for biology2023

Conserved Chamber-Specific Polyploidy Maintains Heart Function in

Archan Chakraborty, Nora G Peterson, Juliet S King, Ryan T Gross, Michelle Mendiola Pla, Aatish Thennavan, Kevin C Zhou, Sophia DeLuca, Nenad Bursac, Dawn E Bowles and 2 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Archan Chakraborty
Nora G Peterson
Juliet S King
Ryan T Gross
Michelle Mendiola Pla
Aatish Thennavan
Kevin C Zhou
Sophia DeLuca
Nenad Bursac
Dawn E Bowles
Matthew J Wolf
Duke University · USThe University of Texas MD Anderson Cancer Center · USUniversity of California, Berkeley · USUniversity of Virginia · US

Funding

ORGANIZATION AND FUNCTIONS OF CELLULAR STRUCTUREST32GM007184 · NIGMS · DUKE UNIVERSITY · PI JINKS-ROBERTSON, SUE · 1985 to 2019
$18.2M
Integrated Cellular and Tissue Engineering for Ischemic Heart DiseaseU01HL134764 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BURSAC, NENAD, KAMP, TIMOTHY J. · 2016 to 2022
$7.7M
Polyploidy after tissue injury: a Drosophila modelR01GM118447 · NIGMS · DUKE UNIVERSITY · PI FOX, DONALD T. · 2016 to 2025
$3.1M
Engineering Human Heart Tissues with Polyploid CardiomyocytesR01HL164013 · NHLBI · DUKE UNIVERSITY · PI BURSAC, NENAD · 2022 to 2025
$2.2M
DYRK1a as a therapeutic target to treat myocardial infarctionR01HL158718 · NHLBI · UNIVERSITY OF VIRGINIA · PI WOLF, MATTHEW J · 2021 to 2024
$1.6M
Polyploidy in Cardiac Development and Tissue Repair in DrosophilaF31HL140811 · NHLBI · DUKE UNIVERSITY · PI PETERSON, NORA GRACE · 2018 to 2020
$118k
NHLBI NIH HHS F31 HL140811NHLBI NIH HHS R01 HL158718NHLBI NIH HHS R01 HL164013NHLBI NIH HHS U01 HL134764NIGMS NIH HHS R01 GM118447NIGMS NIH HHS T32 GM007184
6 · The paper itself

Abstract

Developmentally programmed polyploidy (whole-genome-duplication) of cardiomyocytes is common across evolution. Functions of such polyploidy are essentially unknown. Here, we reveal roles for precise polyploidy levels in cardiac tissue. We highlight a conserved asymmetry in polyploidy level between cardiac chambers in

Identifiers

PMID36798187
PMCPMC9934670
OpenAlexW4320181543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.