Evidence map›Paper›PMID 36798186›Full record

ArticlebioRxiv : the preprint server for biology2023

Glutathione supports lipid abundance

Gloria Asantewaa, Emily T Tuttle, Nathan P Ward, Yun Pyo Kang, Yumi Kim, Madeline E Kavanagh, Nomeda Girnius, Ying Chen, Renae Duncan, Katherine Rodriguez and 28 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

38 authors at 8 institutions in 5 countries.

Gloria AsantewaaDepartment of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Emily T TuttleDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Nathan P WardDepartment of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA, 33612.
Yun Pyo KangDepartment of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA, 33612.
Yumi KimDepartment of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA, 33612.
Madeline E KavanaghDepartment of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA, 92037.
Nomeda GirniusDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA, 02115.
Ying ChenDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA, 06520.
Renae DuncanDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Katherine RodriguezDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Fabio HechtDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Marco ZocchiDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Leonid Smorodintsev-SchillerDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
TashJaé Q ScalesDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Kira TaylorDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Fatemeh AlimohammadiWilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Zachary R SechristWilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Diana Agostini-VulajDepartment of Surgery and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Xenia L SchaferDepartment of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Hayley ChangDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Zachary SmithDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Thomas N O'ConnorDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Sarah WhelanLeicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK.
Laura M SelforsDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA, 02115.
Jett CrowdisDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA, 02115.
G Kenneth GrayDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA, 02115.
Roderick T BronsonDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA, 02115.
Dirk BrennerExperimental & Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, 29 Rue Henri Koch, Esch-sur-Alzette, Luxembourg.
Alessandro RufiniLeicester Cancer Research Centre, University of Leicester, Leicester, LE2 7LX, UK.
Robert T DirksenDepartment of Pharmacology and Physiology, University of Rochester, Rochester, NY, USA, 14642.
Aram F HezelDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Aaron R HuberDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Josh MungerDepartment of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Benjamin F CravattDepartment of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA, 92037.
Vasilis VasiliouDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA, 06520.
Calvin L ColeWilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA, 14642.
Gina M DeNicolaDepartment of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA, 33612.
Isaac S HarrisDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA, 14642.
University of Rochester Medical Center · USHarvard University · USMoffitt Cancer Center · USScripps Research Institute · USUniversity of Leicester · GBYale University · USUniversity of Rochester · USUniversity of Southern Denmark · DK

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
Mouse Models for Alcohol Metabolism and Tissue InjuryR24AA022057 · NIAAA · YALE UNIVERSITY · PI VASILIOU, VASILIS · 2013 to 2022
$4.5M
Investigation of NRF2-Dependent Metabolic LiabilitiesR37CA230042 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI DENICOLA, GINA MARIE · 2018 to 2024
$2.8M
Pathophysiology and Treatment of Recessive RYR1 Related MyopathyR01AR078000 · NIAMS · UNIVERSITY OF ROCHESTER · PI JAMES J DOWLING, Robert T Dirksen · 2020 to 2026
$2.7M
Metabolic modulation by the HCMV UL38 geneR01AI150698 · NIAID · UNIVERSITY OF ROCHESTER · PI JOSHUA C MUNGER · 2020 to 2026
$2.4M
Impact of extracellular glutathione catabolism on triple-negative breast cancerR01CA269813 · NCI · UNIVERSITY OF ROCHESTER · PI Jeevisha Bajaj · 2022 to 2026
$2.2M
Redox Regulation of O-GlcNAcylation Signaling in the Pathogenesis of Alcoholic Fatty Liver DiseaseR01AA028859 · NIAAA · YALE UNIVERSITY · PI Ying Chen · 2022 to 2026
$1.9M
NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA269813NCI NIH HHS R37 CA230042NIAAA NIH HHS R01 AA028859NIAAA NIH HHS R24 AA022057NIAID NIH HHS R01 AI150698NIAMS NIH HHS R01 AR078000Wellcome Trust 210890/Z/18/Z
6 · The paper itself

Abstract

Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is implicated in many diseases, but the requirement for GSH in adult tissues is unclear. To interrogate this, we developed a series of

Indexed as

glutathionelipidsliverNRF2oxidative stress

Identifiers

PMID36798186
PMCPMC9934595
OpenAlexW4320181370

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.