Evidence map›Paper›PMID 36798170›Full record

ArticlebioRxiv : the preprint server for biology2023

The dominance of coinfecting parasites' indirect effects on host traits.

Daniel I Bolnick, Sophia Arruda, Christian Polania, Lauren Simonse, Arshad Padhiar, Andrea Roth, Maria L Rodgers

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Daniel I BolnickDepartment of Ecology and Evolutionary Biology, University of Connecticut, Storrs CT 06269, USA.
Sophia ArrudaDepartment of Ecology and Evolutionary Biology, University of Connecticut, Storrs CT 06269, USA.
Christian PolaniaDepartment of Ecology and Evolutionary Biology, University of Connecticut, Storrs CT 06269, USA.
Lauren SimonseDepartment of Ecology and Evolutionary Biology, University of Connecticut, Storrs CT 06269, USA.
Arshad PadhiarDepartment of Ecology and Evolutionary Biology, University of Connecticut, Storrs CT 06269, USA.
Andrea RothDepartment of Ecology and Evolutionary Biology, University of Connecticut, Storrs CT 06269, USA.
Maria L RodgersDepartment of Ecology and Evolutionary Biology, University of Connecticut, Storrs CT 06269, USA.
University of Connecticut · USNorth Carolina State University · US

Funding

Reciprocal genetics of recently-evolved vertebrate immunity and peritoneal helminth counter-adaptationR01AI123659 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI Daniel Imara Bolnick · 2017 to 2026
$3.8M
NIAID NIH HHS R01 AI123659
6 · The paper itself

Abstract

Indirect genetic effects (IGEs) exist when there is heritable variation in one species' ability to alter a second species' traits. For example, parasites can evolve disparate strategies to manipulate host immune response, whether by evading detection or suppressing immunity. A complication arises during coinfection, when two or more parasite genotypes may try to impose distinct IGEs on the same host trait: which parasite's IGE will be dominant? Here, we apply the notion of dominance to IGEs during coinfection. Using a mathematical model we show that the dominance of IGEs can alter the evolutionary dynamics of parasites. We consider a resident parasite population receiving rare immigrants with a different immune manipulation trait. These immigrants' relative fitness depends on resident prevalence (e.g., the probability immigrants are alone in a host, or coinfecting with a native), and the dominance of the immigrant's IGE on host immunity. Next, we show experimentally that the cestode

Indexed as

Coinfectionecological immunologyeffective migration ratefibrosisGasterosteus aculeatusgene flowSchistocephalus solidusthreespine stickleback

Identifiers

PMID36798170
PMCPMC9934634
OpenAlexW4320179476

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.