Evidence map›Paper›PMID 36798167›Full record

ArticlebioRxiv : the preprint server for biology2023

Planarian LDB and SSDP proteins scaffold transcriptional complexes for regeneration and patterning.

Taylor Medlock-Lanier, Kendall B Clay, Rachel H Roberts-Galbraith

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Taylor Medlock-LanierDepartment of Cellular Biology, University of Georgia, Athens, GA, USA.
Kendall B ClayNeuroscience Program, University of Georgia, Athens, GA, USA.
Rachel H Roberts-GalbraithDepartment of Cellular Biology, University of Georgia, Athens, GA, USA.
University of Georgia · US

Funding

T32 Predoctoral Training Grant in GeneticsT32GM142623 · NIGMS · UNIVERSITY OF GEORGIA · PI Kelly A Dyer, Mary Grace Goll · 2022 to 2026
$2.1M
Mechanisms Driving Regenerative Neurogenesis in PlanariansR01NS128096 · NINDS · UNIVERSITY OF GEORGIA · PI Rachel Helen Roberts-Galbraith · 2022 to 2026
$1.8M
Diversity MATTERS in Neuroscience TrainingR25NS107179 · NINDS · UNIVERSITY OF GEORGIA · PI COFFIELD, JULIE A, LAUDERDALE, JAMES D · 2018 to 2023
$1.3M
NIGMS NIH HHS T32 GM142623NINDS NIH HHS R01 NS128096NINDS NIH HHS R25 NS107179
6 · The paper itself

Abstract

Sequence-specific transcription factors often function as components of large regulatory complexes. LIM-domain binding protein (LDB) and single-stranded DNA-binding protein (SSDP) function as core scaffolds of transcriptional complexes in animals and plants. Little is known about potential partners and functions for LDB/SSDP complexes in the context of tissue regeneration. In this work, we find that planarian LDB1 and SSDP2 promote tissue regeneration, with a particular function in mediolateral polarity reestablishment. We find that LDB1 and SSDP2 interact with one another and with characterized planarian LIM-HD proteins Arrowhead, Islet1, and Lhx1/5-1.

Identifiers

PMID36798167
PMCPMC9934679
OpenAlexW4319590580

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.