ArticleJournal of veterinary internal medicine2023
Clinical features of muscle stiffness in 37 dogs with concurrent naturally occurring hypercortisolism.
Article in Journal of veterinary internal medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Effect of trilostane treatment on proteinuria secondary to spontaneous hypercortisolism in dogs.Journal of veterinary internal medicine · 2026Article
- Case Report: Suspected "stiff dog syndrome" in a Maltese dog.Frontiers in veterinary science · 2025Article
- Cushing's Myopathy in Dogs: Prevalence, Clinical Abnormalities, and Response to Treatment.Animals : an open access journal from MDPI · 2024Article
- Trismus due to myotonia associated with hyperadrenocorticism in a dog.The Journal of veterinary medical science · 2023Article
- Clinical features of muscle stiffness in 37 dogs with concurrent naturally occurring hypercortisolism.Journal of veterinary internal medicine · 2023Article
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Authors and funding
15 authors at 11 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSevere muscle stiffness (SMS) in dogs with hypercortisolism (HC) is uncommon.
objectivesTo evaluate signalment, presentation, treatments, and long-term outcomes of dogs with concurrent HC and SMS. ANIMALS: Thirty-seven dogs.
methodsMedical records of dogs with HC and concurrent SMS were recruited from 10 institutions. Clinical information, test results, therapeutic responses, and survival times were reviewed.
resultsAll 37 dogs with HC and SMS had pituitary-dependent hypercortisolism (PDH); 36/37 weighed <20 kg. Signs and test results were typical of PDH aside from SMS, initially diagnosed in all 4 limbs in 9, pelvic limbs of 22, and thoracic limbs of 6 dogs. Hypercortisolism and SMS were diagnosed together in 3 dogs; HC 1-36 months before SMS in 23; SMS 1-12 months before HC in 11. Mitotane or trilostane, given to control HC in 36/37 dogs, improved or resolved HC signs in 28; SMS did not resolve, remaining static or worsening in 31/36 dogs, mildly improving in 5/19 dogs given additional therapies. Progression of SMS included additional limbs in 10 dogs and the masticatory muscles of 2. The median survival time from diagnosis of SMS was 965 days (range, 8-1188). CONCLUSIONS AND CLINICAL IMPORTANCE: Concurrent SMS and HC is uncommon, possibly affecting only dogs with PDH. Development of SMS might occur before or after diagnosis of HC. Apart from SMS, the clinical picture and survival time of these dogs seem indistinguishable from those of dogs with HC in general. However, while muscle weakness usually resolves with HC treatment SMS does not.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.