ArticleBrain : a journal of neurology2023
An anti-amyloid therapy works for Alzheimer's disease: why has it taken so long and what is next?
Article in Brain : a journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Primary age-related tauopathy.Acta neuropathologica · 2025Review
- Identifying latent classes of longitudinal change in picture naming in a population-based sample.Aging clinical and experimental research · 2025Article
- Alzheimer's Disease: Treatment Challenges for the Future.Journal of neurochemistry · 2025Review
- Use of Amyloid Positron-Emission Tomography to Diagnose Alzheimer's Disease in Clinical Practice in South Korea: Expert Recommendations.Journal of clinical neurology (Seoul, Korea) · 2025Review
- Longitudinal tau aggregation, atrophy, and cognitive decline in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Article
- What are the reasons for the repeated failures of clinical trials with anti-amyloid drugs for AD treatment?Dementia & neuropsychologia · 2025Article
- White matter hyperintensity on MRI and plasma Aβ42/40 ratio additively increase the risk of cognitive impairment in hypertensive adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Considering challenges for the new Alzheimer's drugs: Clinical, population, and health system perspectives.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- It's good to know what to BACE the specificity of your inhibitors on.The Journal of clinical investigation · 2024Article
- Stress testing the Centiloid: Precision and variability of PET quantification of amyloid pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- [International journal of molecular sciences · 2024Article
- Alzheimer's disease: part 2 - the present.Arquivos de neuro-psiquiatria · 2024Review
- The Enigma of Tau Protein Aggregation: Mechanistic Insights and Future Challenges.International journal of molecular sciences · 2024Review
- [Neurology international · 2024Article
- Examining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Estimated effects of amyloid reduction on cognitive change: A Bayesian update across a range of priors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Evaluating clinical meaningfulness of anti-β-amyloid therapies amidst amyloid-related imaging abnormalities concern in Alzheimer's disease.Brain communications · 2024Review
- Intranasal Drug Delivery by Nanotechnology: Advances in and Challenges for Alzheimer's Disease Management.Pharmaceutics · 2023Review
- Switching On/Off Amyloid Plaque Formation in Transgenic Animal Models of Alzheimer's Disease.International journal of molecular sciences · 2023Review
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Commented on by
Authors and funding
2 authors.
Funding
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.