ArticleCardiovascular diabetology2023
Triglyceride-glucose index and triglyceride to high-density lipoprotein cholesterol ratio as potential cardiovascular disease risk factors: an analysis of UK biobank data.
Article in Cardiovascular diabetology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 255 papers, 3 of them syntheses that pooled it.
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Who cites it
255 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The modifying effect of diabetes on the association between triglyceride to high-density lipoprotein cholesterol ratio and cardiovascular risk: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2026Pooled it
- Pooled it
- The association between the triglyceride-glucose index and vitamin D status: a systematic review and meta-analysis.BMC endocrine disorders · 2024Pooled it
- Antecedent, landmark, and two-visit cumulative triglyceride-glucose index and non-traditional lipid measures in relation to incident cardiovascular disease in adults with cardiovascular-kidney-metabolic syndrome (CKM) stages 0-3: a nationwide prospective cohort study.Cardiovascular diabetology · 2026Article
- Triglyceride glucose index, metabolic comorbidity, and cardiovascular disease: a national cohort study.BMC cardiovascular disorders · 2026Article
- HDL cholesterol indicates neurodegenerative vulnerability in dementia with lewy bodies.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- The triglyceride-glucose index as a measure of insulin resistance and risk of incident endometrial cancer: a prospective analysis in UK Biobank.Journal of gynecologic oncology · 2026Article
- Association between lipid comprehensive index and carotid atherosclerosis: evidence from a large-scale ultrasound screening program.Internal and emergency medicine · 2026Article
- Ratio That Reveals Risk: Defining TG:HDL-C Ratio Cutoff for Insulin Resistance in Adolescents with Obesity.Children (Basel, Switzerland) · 2026Article
- Reconceptualizing Dyslipidemia: Diversity of Lipid Imbalances and Their Clinical Implications; A Narrative Review.Health science reports · 2026Article
- Article
- Association between insulin resistance-related indices and the risk of recurrence after catheter ablation in patients with nonvalvular atrial fibrillation.Cardiovascular diabetology · 2026Observational
- Blood-labyrinth barrier disruption associates with hypercholesterolemia-induced hearing loss.iScience · 2026Article
- Association between the triglyceride-glucose index and urinary albumin-to-creatinine ratio in patients with early-onset type 2 diabetes.BMC endocrine disorders · 2026Observational
- Association of C-Reactive Protein-Triglyceride Glucose Index and TyG Index With Prehypertension and Hypertension.Immunity, inflammation and disease · 2026Article
- Correlation Between the Atherogenic Index of Plasma and Major Adverse Long-Term Prognosis in Patients With Coronary Artery Disease and Stage 2-5 Chronic Kidney Disease.Reviews in cardiovascular medicine · 2026Article
- Observational
- Correlation between surrogate indicators of insulin resistance and all-cause mortality in patients with severe hemorrhagic stroke: a multicenter retrospective cohort study in the United States.Cardiovascular diabetology · 2026Article
- Longitudinal changes and cumulative exposure of cardiometabolic index predict cardiovascular disease risk in middle-aged and older adults: a national prospective cohort study.BMC cardiovascular disorders · 2026Article
- Non-insulin-dependent insulin resistance surrogate indexes for predicting chronic kidney disease in diabetic individuals: a prospective cohort study.BMC endocrine disorders · 2026Article
195 more citing papers are in PubMed but not listed here.
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7 authors.
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Abstract
backgroundThe triglyceride-glucose (TyG) index and triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, two simple surrogate indicators of insulin resistance, have been demonstrated to predict cardiovascular disease (CVD). However, very few studies have investigated their associations with CVD in European populations.
methodsA total of 403,335 participants from the UK Biobank with data for TyG index and TG/HDL-C ratio and free from CVD at baseline were included. Cox models were applied to evaluate the association between TyG index and TG/HDL-C ratio and incident CVD. Mediation analyses were performed to evaluate the contribution of prevalent diabetes, hypertension, and dyslipidemia to observed associations.
resultsDuring a median follow-up of 8.1 years, 19,754 (4.9%) individuals developed CVD, including 16,404 (4.1%) cases of CHD and 3976 (1.0%) cases of stroke. The multivariable-adjusted hazard ratios of total CVD in higher quartiles versus the lowest quartiles were 1.05, 1.05, and 1.19, respectively, for TyG index, and 1.07, 1.13, and 1.29, respectively, for TG/HDL-C ratio. There were significant trends toward an increasing risk of CVD across the quartiles of TyG index and TG/HDL-C ratio. In mediation analyses, dyslipidemia, type 2 diabetes, and hypertension explained 45.8%, 27.0%, and 15.0% of TyG index's association with CVD, respectively, and 40.0%, 11.8%, and 13.3% of TG/HDL-C ratio's association with CVD, respectively.
conclusionsElevated baseline TyG index and TG/HDL-C ratio were associated with a higher risk of CVD after adjustment for the well-established CVD risk factors. These associations were largely mediated by greater prevalence of dyslipidemia, type 2 diabetes, and hypertension.
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