Evidence map›Paper›PMID 36797680›Full record

Observational studyBMC anesthesiology2023

Pharmacogenetics in critical care: association between CYP3A5 rs776746 A/G genotype and acetaminophen response in sepsis and septic shock.

C Scorcella, R Domizi, S Amoroso, A Carsetti, E Casarotta, P Castaldo, C D'angelo, E Damiani, F Gasparri, A Donati and 1 more

Registry-linked trialOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC anesthesiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02750163 (Circulating Free Hemoglobin and Microcirculation After Administration of Paracetamol in Febrile Septic Patient), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02750163 completednot on this map

Circulating Free Hemoglobin and Microcirculation After Administration of Paracetamol in Febrile Septic Patient

TypeobservationalSponsorUniversità Politecnica delle MarcheRan2017 to 2019Enrolled50ConditionsSepsis and Septic ShockArmsparacetamol
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Genetic PolymorphismsPharmaceuticals (Basel, Switzerland) · 2026
    Article
  2. OncoTargets and therapy · 2025
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

C ScorcellaAnesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria delle Marche, via Conca 71, Torrette di Ancona, 60126, Italy.
R DomiziAnesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria delle Marche, via Conca 71, Torrette di Ancona, 60126, Italy.
S AmorosoDepartment of Biomedical Sciences and Public Health, Università Politecnica Delle Marche, via Tronto 10/a, Torrette di Ancona, 60020, Italy.
A CarsettiAnesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria delle Marche, via Conca 71, Torrette di Ancona, 60126, Italy.
E CasarottaAnesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria delle Marche, via Conca 71, Torrette di Ancona, 60126, Italy.
P CastaldoDepartment of Biomedical Sciences and Public Health, Università Politecnica Delle Marche, via Tronto 10/a, Torrette di Ancona, 60020, Italy.
C D'angeloAnesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria delle Marche, via Conca 71, Torrette di Ancona, 60126, Italy.
E DamianiAnesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria delle Marche, via Conca 71, Torrette di Ancona, 60126, Italy.
F GasparriAnesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria delle Marche, via Conca 71, Torrette di Ancona, 60126, Italy.
A DonatiAnesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria delle Marche, via Conca 71, Torrette di Ancona, 60126, Italy. a.donati@univpm.it.
E AdrarioAnesthesia and Intensive Care Unit, Azienda Ospedaliero Universitaria delle Marche, via Conca 71, Torrette di Ancona, 60126, Italy.
Marche Polytechnic University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPharmacogenetics could represent a further resource to understand the interindividual heterogeneity of response of the host to sepsis and to provide a personalized approach to the critical care patient.

methodsSecondary analysis of data from the prospective observational study NCT02750163, in 50 adult septic and septic shock patients treated with Acetaminophen (ACT) for pyrexia. We investigated the presence of two polymorphisms, located respectively in the genes UGT1A1 and CYP3A5, that encode for proteins related to the hepatic metabolism of ACT. The main dependent variables explored were plasmatic concentration of ACT, body temperature and hepatic parameters.

results8% of the patients carried CYP3A5 rs776746 A/G genotypes and showed significantly higher plasma levels of ACT than GG wild type patients, and than patients with UGT1A1 rs8330 C/G genotypes.

conclusionsIdentifying specific genotypes of response to ACT may be helpful to guide a more personalized titration of therapy in sepsis and septic shock. CYP3A5 might be a good biomarker for ACT metabolism; however further studies are needed to confirm this result.

trial registrationNCT02750163.

Indexed as

SepsisShock, SepticAcetaminophenAdultCritical CareCytochrome P-450 CYP3AGenotypeHumansPharmacogeneticsAcetaminophenCYP3A5 protein, humanCytochrome P-450 CYP3AAcetaminophenParacetamolPersonalizationPharmacogeneticPharmacogenomicSepsisSeptic shock

Identifiers

PMID36797680
PMCPMC9933278
OpenAlexW4321099961

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.