Evidence map›Paper›PMID 36797668›Full record

ArticleBMC cancer2023

Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition.

S G Yammine, I Huybrechts, C Biessy, L Dossus, S Panico, M J Sánchez, V Benetou, R Turzanski-Fortner, V Katzke, A Idahl and 32 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 20 institutions in 13 countries.

S G YammineUniversité Sorbonne Paris Nord and Université Paris Cité, INSERM, INRAE, CNAM, Center of Research in Epidemiology and StatisticS (CRESS) , Nutritional Epidemiology Research Team (EREN), F-93017, Bobigny, France. sahar.yammine@eren.smbh.univ-paris13.fr.
I HuybrechtsInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
C BiessyInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
L DossusInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
S PanicoDipartimento di medicina clinica e chirurgia, Federico II University, Naples, Italy.
M J SánchezEscuela Andaluza de Salud Pública (EASP), Granada, Spain.
V BenetouDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Grèce.
R Turzanski-FortnerThe German Cancer Research Center (DKFZ), Heidelberg, Germany.
V KatzkeThe German Cancer Research Center (DKFZ), Heidelberg, Germany.
A IdahlDepartment of Clinical Sciences, Obstetrics and Gynecology, Umeå University, Umeå, Sweden.
G SkeieFaculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, N - 9037, Tromsø, Norway.
K Standahl OlsenFaculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, N - 9037, Tromsø, Norway.
A TjønnelandDanish Cancer Society Research Center, Copenhagen, Denmark.
J HalkjaerDanish Cancer Society Research Center, Copenhagen, Denmark.
S Colorado-YoharCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
A K HeathDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom.
E SonestedtDepartment of Clinical Sciences Malmö, Lund University, Sweden.
H SartorDepartment of Clinical Sciences Malmö, Lund University, Sweden.
M B SchulzeDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam- Rehbruecke, Nuthetal, Germany.
D PalliCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.
M Crous-BouUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO) - Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat, 08908, Barcelona, Spain.
A DorronsoroMinistry of Health of the Basque Government, Sub-Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain.
K OvervadDepartment of Public Health, Aarhus University, Aarhus, Denmark.
A Barricarte GurreaCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
G SeveriCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia.
R C H VermeulenJulius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands.
T M SandangerFaculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, N - 9037, Tromsø, Norway.
R C TravisCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
T KeyCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
P AmianoMinistry of Health of the Basque Government, Sub-Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain.
B Van GuelpenCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
M JohanssonInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
M SundDepartment of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden.
R TuminoCancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), Ragusa, Italy.
N WarehamMRC Epidemiology Unit, University of Cambridge, Cambridge, England, U.K.
C SacerdoteUnit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Via Santena 7, 10126, Turin, Italy.
V KroghEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori Di, Milano, Italy.
P BrennanInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
E RiboliDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom.
E WeiderpassInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
M J Gunter *International Agency for Research on Cancer, World Health Organization, Lyon, France.
V Chajès *International Agency for Research on Cancer, World Health Organization, Lyon, France.
Centre international de recherche sur le cancer · FRUiT The Arctic University of Norway · NOBasque Government · ESGerman Cancer Research Center · DEImperial College London · GBLund University · SEUmeå University · SEUniversity of Oxford · GBAarhus University · DKConservatoire National des Arts et Métiers · FRDanish Cancer Society · DKFederico II University Hospital · ITFondazione IRCCS Istituto Nazionale dei Tumori · ITHarvard University · USInserm · FRInstituto de Salud Pública de Navarra · ESMRC Epidemiology Unit · GBNational and Kapodistrian University of Athens · GRPiedmont Reference Center for Epidemiology and Cancer Prevention · ITThe University of Melbourne · AU

Funding

Cancer Research UK 29017Medical Research Council MC_UU_00006/1Medical Research Council MR/M012190/1Medical Research Council MR/N003284/1World Health Organization 001
6 · The paper itself

Abstract

backgroundDiet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).

methodsThis analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons.

resultsConsumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintile

conclusionOur results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.

Indexed as

Endometrial Neoplasmsgamma-Linolenic AcidAnimalsDietFatty AcidsFemaleHumansProspective StudiesRisk FactorsFatty Acidsgamma-Linolenic AcidDietEndometrial cancerEpidemiologyFatty acids

Identifiers

PMID36797668
PMCPMC9936701
OpenAlexW4321084020

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.