Evidence map›Paper›PMID 36797524›Full record

ArticleArchives of gynecology and obstetrics2023

High estradiol levels during a long agonist IVF protocol are associated with decreased food intake, higher leptin concentrations, and lower levels of high-sensitivity C-reactive protein.

Jonna Leppänen, Petrus Nuotio, Kaisa Randell, Jarkko Romppanen, Leea Keski-Nisula, Tomi Laitinen, Jussi Pihlajamäki, Ursula Schwab, Seppo Heinonen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of gynecology and obstetrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jonna LeppänenDepartment of Obstetrics and Gynecology, Kuopio University Hospital and University of Eastern Finland, Puijonlaaksontie 2, 70210, Kuopio, Finland. jonna.leppanen@kuh.fi.ORCID 0000-0001-5201-295X
Petrus NuotioInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, P.O. Box 1627, 70211, Kuopio, Finland.
Kaisa RandellPihlajalinna Dextra Fertility Clinic, Helsinki, Finland.
Jarkko RomppanenEastern Finland Laboratory Centre, Puijonlaaksontie 2, 70210, Kuopio, Finland.
Leea Keski-NisulaDepartment of Obstetrics and Gynecology, Kuopio University Hospital and University of Eastern Finland, Puijonlaaksontie 2, 70210, Kuopio, Finland.
Tomi LaitinenDepartment of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Puijonlaaksontie 2, 70210, Kuopio, Finland.
Jussi PihlajamäkiInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, P.O. Box 1627, 70211, Kuopio, Finland.
Ursula SchwabInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, P.O. Box 1627, 70211, Kuopio, Finland.
Seppo HeinonenObstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, PO Box 140, 00029, Helsinki, Finland.
University of Eastern Finland · FIEastern Finland Laboratory Center · FIUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo study whether different hormonal phases affect appetite regulation, food intake, and concentrations of leptin, glucagon-like peptide-1 (GLP-1), and high-sensitivity C-reactive protein (hs-CRP) during a long agonist in vitro fertilization (IVF) protocol.

methodsFifty-four infertile women were encountered thrice, the first of which was at the beginning of their period (low estradiol). The other two visits were during a gonadotrophin-releasing hormone (GnRH) analog downregulation (low estradiol) and at the end of a follicle-stimulating hormone (FSH) stimulation (high estradiol). The first visit was the reference; the women served as their controls. The concentrations of leptin, GLP-1, and hs-CRP were assessed from plasma. Dietary intake was assessed using food records (FRs). In addition, weight, height, body mass index (BMI), and plasma levels of estradiol, glucose, HbA1c, insulin, and lipids were monitored. Twenty-six of the subjects also had a postprandial test.

resultsDuring the stimulation protocol, leptin concentrations elevated (P < 0.001), and energy intake decreased (P = 0.03), while estradiol levels increased (P < 0.001). GLP-1 levels unchanged (P = 0.75) and hs-CRP (P = 0.03) concentrations diminished, while estradiol levels increased.

conclusionNo increased food intake or weight gain occurred during the stimulation protocol; thus, leptin may protect from overeating during high estradiol levels, and leptin resistance may not occur during a short follow-up. Also, a favorable anti-inflammatory effect was detected. During this study, we observed no harmful metabolic effects, which might affect negatively maternal health.

Indexed as

Infertility, FemaleLeptinC-Reactive ProteinEatingEstradiolFemaleFertilization in VitroFollicle Stimulating HormoneGlucagon-Like Peptide 1Gonadal Steroid HormonesHumansC-Reactive ProteinEstradiolFollicle Stimulating HormoneGlucagon-Like Peptide 1Gonadal Steroid HormonesLeptinAppetite regulationEstradiolInfertilityIn vitro fertilizationLeptin

Identifiers

PMID36797524
PMCPMC10348986
OpenAlexW4321077641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.