ReviewNature medicine2023
New and emerging approaches to treat psychiatric disorders.
Review in Nature medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Resting-state EEG activity in depression: a systematic review and meta-analysis.NeuroImage. Clinical · 2026Pooled it
- Efficacy of transcranial magnetic stimulation in the treatment of combat-related PTSD: a systematic review and meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Neural correlates of peripartum depression: a systematic review, meta-analysis and comparison to major depressive disorder.Molecular psychiatry · 2025Pooled it
- Reframing stress adaptation as a dynamic system failure along a threat-response continuum: towards a phase-specific, mechanism-driven framework.Molecular psychiatry · 2026Article
- Big data and psychiatry: advances, constraints and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Mechanisms of Selective Serotonin Reuptake Inhibitors in Treatment-Resistant Obsessive-Compulsive Disorder: Cortico-Striatal Circuitry, Glutamatergic Dysregulation, and Neuroplastic Constraints.Molecular neurobiology · 2026Review
- Computational-Experimental Characterization of Transcranial Magneto-Acoustic Stimulation for Dose-Efficient Neural Activation.Brain sciences · 2026Article
- Causal association between cataract and psychiatric disorders: A bidirectional 2-sample Mendelian randomization study.Medicine · 2026Article
- Integrating biological pathway polygenic scores and trauma in psychosis: findings from the EU-GEI study.Translational psychiatry · 2026Article
- Standardized chronic restraint stress protocols reveal dynamic evolution of behavioral adaptations in male mice: implications for translational neuroscience.Molecular psychiatry · 2026Article
- State-Dependent Modulation of a Theta-Responsive Subnetwork by High-Frequency Stimulation of the Ventral Striatum.Neuroscience bulletin · 2026Article
- Persistent homology of blood gene co-expression networks reveals reduced cycle structure in autism spectrum disorder: a multi-cohort analysis.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Microglia-mediated synaptic pruning in neural circuit remodeling: multidimensional control in homeostasis and neuropathology.BMC medicine · 2026Review
- Intermittent Ketamine and Neuromodulation Treatment Evoke Synergistic Antidepressant-Relevant Action.Biological psychiatry · 2026Article
- An emerging theoretical lens post global epidemic and turmoil: Psychological immunity.Dialogues in health · 2026Review
- Self-treatment of psychiatric conditions using ketamine: Patterns, characteristics, and retrospective insights.Journal of psychopharmacology (Oxford, England) · 2026Article
- Human-Derived Cellular Models in Psychiatry: A Focus on the Olfactory Neuroepithelium.Brain sciences · 2026Review
- Brain network representations of placebo analgesia.Psychological medicine · 2026Article
- Decoding causal m6A: a bioinformatics roadmap for psychiatric disorders.Briefings in bioinformatics · 2026Review
- Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Psychiatric disorders are highly prevalent, often devastating diseases that negatively impact the lives of millions of people worldwide. Although their etiological and diagnostic heterogeneity has long challenged drug discovery, an emerging circuit-based understanding of psychiatric illness is offering an important alternative to the current reliance on trial and error, both in the development and in the clinical application of treatments. Here we review new and emerging treatment approaches, with a particular emphasis on the revolutionary potential of brain-circuit-based interventions for precision psychiatry. Limitations of circuit models, challenges of bringing precision therapeutics to market and the crucial advances needed to overcome these obstacles are presented.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.