Evidence map›Paper›PMID 36797461›Full record

Trial reportQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2023

Psychological interventions improve quality of life despite persistent pain in endometriosis: results of a 3-armed randomized controlled trial.

K E Hansen, B Brandsborg, U S Kesmodel, A Forman, M Kold, R Pristed, O Donchulyesko, D Hartwell, L Vase

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02761382 (Mindfulness-based Psychological Pain Treatment in Endometriosis), which is not on this map. Cited by 29 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 8 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02761382 nacompletednot on this map

Mindfulness-based Psychological Pain Treatment in Endometriosis

TypeinterventionalSponsorUniversity of AarhusRan2016 to 2018Enrolled58ConditionsEndometriosis, Pelvic Pain, Chronic PainArmsMindfulness-based psychological treatment, Non-specific psychological treatment
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 8 syntheses or guidelines pooled it, 44 citations in OpenAlex.

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  5. Biopsychosocial Approaches for the Management of Female Chronic Pelvic Pain: A Systematic Review.BJOG : an international journal of obstetrics and gynaecology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

K E HansenDepartment of Public Health, Aarhus University, Bartholins Allé 2, 8000, Aarhus, Denmark. keh@ph.au.dk.ORCID http://orcid.org/0000-0003-0243-7399
B BrandsborgDepartment of Clinical Medicine, Aarhus University, 8210, Aarhus, Denmark.
U S KesmodelDepartment of Obstetrics and Gynaecology, Aalborg University Hospital, 9000, Aalborg, Denmark.ORCID http://orcid.org/0000-0003-3868-106X
A FormanDepartment of Clinical Medicine, Aarhus University, 8210, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-1369-1296
M KoldDepartment of Communication and Psychology, The Faculty of Social Sciences and Humanities (SSH), Aalborg University, 9000, Aalborg, Denmark.ORCID http://orcid.org/0000-0002-6878-4206
R PristedDepartment of Psychological Health, Agder University, Agder, Norway.
O DonchulyeskoDepartment of Obstetrics and Gynaecology, North Denmark Regional Hospital, Hjørring, Denmark.
D HartwellDepartment of Gynaecology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
L VaseDepartment of Psychology and Behavioral Sciences, School of Business and Social Sciences, Aarhus University, 8000, Aarhus, Denmark.
Aarhus University · DKAalborg University · DKAalborg University Hospital · DKCopenhagen University Hospital · DKNorth Denmark Region · DKUniversity of Agder · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDespite standard medical treatment endometriosis is often associated with disabling pain and poor quality of life (QoL). Studies indicate that psychological interventions (PIs) may improve pain and QoL, yet studies on the effects of PIs for women with endometriosis are sparse and limited by low-quality study designs. Therefore, this study aimed, in a rigorous three-armed design, to evaluate the effect of PIs on chronic pelvic pain (CPP) and QoL in women with endometriosis.

methodsThis three-armed parallel, multi-center randomized controlled trial included fifty-eight endometriosis patients reporting severe CPP [≥ 5 for pain intensity measured on a 0-10-point numeric rating scale (NRS)]. Patients were randomly assigned to (1) Specific mindfulness- and acceptance-based psychological intervention (MY-ENDO), (2) Carefully matched non-specific psychological intervention (Non-specific), or (3) A wait-list control group (WL). The primary outcome was pelvic pain intensity/unpleasantness measured on NRS. Secondary outcomes included endometriosis-related quality of life, workability, pain acceptance, and endometriosis-related symptoms. Differences in outcomes between groups at post-treatment follow-up were analyzed using mixed linear models. Analyses were performed on an intention-to-treat basis.

resultsCompared to WL, psychological intervention (MY-ENDO + Non-specific) did not significantly reduce pain. However, psychological intervention did significantly improve the QoL-subscales 'control and powerlessness', 'emotional well-being', and 'social support' as well as the endometriosis-related symptoms 'dyschezia' and 'constipation'. MY-ENDO was not superior to Non-specific.

conclusionsWomen with endometriosis may have significant and large effects of psychological intervention on QoL despite an ongoing experience of severe CPP.

trial registration12 April 2016, clinicaltrials.gov (NCT02761382), retrospectively registered.

Indexed as

EndometriosisEmotionsFemaleHumansPelvic PainPsychosocial InterventionQuality of LifeAcceptance and commitment therapyChronic pelvic painControl conditionEndometriosisMindfulnessPsychotherapyQuality of life

Identifiers

PMID36797461
PMCPMC10172241
OpenAlexW4321015453

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.