ArticleScientific reports2023
Association between knee osteoarthritis and the risk of cardiovascular disease and the synergistic adverse effects of lack of exercise.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Mortality risk in osteoarthritis patients: a meta-analysis of observational studies.BMC musculoskeletal disorders · 2025Pooled it
- Are Exercise Interventions for People With Knee Osteoarthritis Dosed Appropriately to Meet the World Health Organisation's Physical Activity Guidelines?Musculoskeletal care · 2025Pooled it
- Just-in-Time Adaptive Interventions for Behavior Change in Physiological Health Outcomes and the Use Case for Knee Osteoarthritis: Systematic Review.Journal of medical Internet research · 2024Pooled it
- Changes in cardiovascular health following ischemic preconditioning in older adults with knee osteoarthritis.Physiological reports · 2025Trial
- Emerging therapies for knee osteoarthritis.Nature reviews. Rheumatology · 2026Review
- TNFR2 Agonism as a Sex-Specific Therapy for Novel Osteoarthritis-Induced Cardiac Dysfunction.bioRxiv : the preprint server for biology · 2026Article
- Pathological mechanisms of osteoarthritis in the network of geriatric comorbidities: Emerging insights from organs-crosstalk.Journal of orthopaedic translation · 2026Review
- Association between digestive diseases and symptomatic knee osteoarthritis in Chinese participants: a prospective cohort study.BMC public health · 2026Article
- Does physical activity reduce cardiovascular risk associated with knee osteoarthritis in type 2 diabetes? A nationwide cohort study.The Korean journal of internal medicine · 2026Article
- Integrated Multiomics Analysis Identifies CDO1 as a Novel Therapeutic Target for OsteoarthritisEndocrine, metabolic & immune disorders drug targets · 2026Article
- Teratoma-free cartilage regeneration using p21-/- iPSCs engineered with iCasp9.Stem cells translational medicine · 2025Article
- Glucagon-like peptide-1 receptor agonists in arthritis: current insights and future directions.Nature reviews. Rheumatology · 2025Review
- Risk of all-cause mortality in patients with knee osteoarthritis: A systematic review and meta-analysis of cohort studies.Osteoarthritis and cartilage open · 2025Review
- Advances and Challenges in the Pursuit of Disease-Modifying Osteoarthritis Drugs: A Review of 2010-2024 Clinical Trials.Biomedicines · 2025Review
- The effect of whole-body electromyostimulation on metabolic syndrome in affected adults: A subanalysis of a randomized controlled trial.Frontiers in sports and active living · 2025Article
- Applying EASIX in Osteoarthritis. The Link between Inflammation and Cardiovascular Risk.Arquivos brasileiros de cardiologia · 2025Article
- The Role of mRNA Modifications in Bone Diseases.International journal of biological sciences · 2025Review
- Impact of a Semi-Rigid Knee Orthotic Intervention on Pain, Physical Activity, and Functional Capacity in Patients with Medial Knee Osteoarthritis.Journal of clinical medicine · 2024Article
- The Knee-SCHOOL: a brief patient-centered multidisciplinary educational program for knee osteoarthritis.Frontiers in medicine · 2024Article
- Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to determine whether knee OA is associated with CVD risk and all-cause death and to evaluate whether the association differs by exercise behavior. We used Korea National Health Insurance Service (KNHIS) database and included 201,466 participants (7572 subjects diagnosed with knee OA) who underwent health screening between 2009 and 2015. Those who had been diagnosed with knee OA or CVD before the index year were excluded. Cox proportional hazard models were used after adjusting for sociodemographic and CVD risk factors to evaluate the association between knee OA and CVD risk and all-cause death. Stratification analysis was further performed to determine the effect of exercise behavior on this relationship. During a median follow-up of 7.06 ± 2.24 years, 8743 CVD (2510 MI and 6553 stroke) cases developed. Individuals with knee OA had increased risks of CVD [hazard ratio (HR) 1.26, 95% confidence interval (CI) 1.15-1.38], myocardial infarction (MI) (HR 1.20, 95% CI 1.00-1.44), and stroke (HR 1.29, 95% CI 1.16-1.43) compared with those without knee OA. Those with knee OA who did not exercise had an increased risk of CVD (HR 1.25, 95% CI 1.11-1.40), whereas no significant increased CVD risk was observed in those with knee OA who exercised at least once a week (HR 1.11, 95% CI 0.96-1.28). There was no association between knee osteoarthritis and all-cause death. Knee OA was independently associated with an increased risk of CVD. Lack of exercise might have a synergistic adverse effect on the association between knee OA and CVD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.