Evidence map›Paper›PMID 36797059›Full record

ArticleNeurology2023

Clinical Reasoning: Progressive Hemiparesis and White Matter Abnormalities in an HIV-Negative Patient.

Edwin Jabbari, Fernanda Ruiz, Simon F K Lee, Farrah Jabeen, Sebastian Brandner, Desmond P Kidd, Hadi Manji, Amit Batla

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Edwin JabbariFrom the Department of Neurology (E.J., S.F.K.L., F.J., D.P.K., A.B.), Royal Free Hospital NHS Foundation Trust; The National Hospital for Neurology and Neurosurgery (E.J., F.J., H.M., A.B.), University College London Hospitals NHS Foundation Trust; and Division of Neuropathology (F.R., S.B.), UCL Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, United Kingdom. edwin.jabbari@nhs.net.ORCID 0000-0001-6844-882X
Fernanda RuizFrom the Department of Neurology (E.J., S.F.K.L., F.J., D.P.K., A.B.), Royal Free Hospital NHS Foundation Trust; The National Hospital for Neurology and Neurosurgery (E.J., F.J., H.M., A.B.), University College London Hospitals NHS Foundation Trust; and Division of Neuropathology (F.R., S.B.), UCL Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, United Kingdom.
Simon F K LeeFrom the Department of Neurology (E.J., S.F.K.L., F.J., D.P.K., A.B.), Royal Free Hospital NHS Foundation Trust; The National Hospital for Neurology and Neurosurgery (E.J., F.J., H.M., A.B.), University College London Hospitals NHS Foundation Trust; and Division of Neuropathology (F.R., S.B.), UCL Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, United Kingdom.
Farrah JabeenFrom the Department of Neurology (E.J., S.F.K.L., F.J., D.P.K., A.B.), Royal Free Hospital NHS Foundation Trust; The National Hospital for Neurology and Neurosurgery (E.J., F.J., H.M., A.B.), University College London Hospitals NHS Foundation Trust; and Division of Neuropathology (F.R., S.B.), UCL Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, United Kingdom.
Sebastian BrandnerFrom the Department of Neurology (E.J., S.F.K.L., F.J., D.P.K., A.B.), Royal Free Hospital NHS Foundation Trust; The National Hospital for Neurology and Neurosurgery (E.J., F.J., H.M., A.B.), University College London Hospitals NHS Foundation Trust; and Division of Neuropathology (F.R., S.B.), UCL Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, United Kingdom.ORCID 0000-0002-9821-0342
Desmond P KiddFrom the Department of Neurology (E.J., S.F.K.L., F.J., D.P.K., A.B.), Royal Free Hospital NHS Foundation Trust; The National Hospital for Neurology and Neurosurgery (E.J., F.J., H.M., A.B.), University College London Hospitals NHS Foundation Trust; and Division of Neuropathology (F.R., S.B.), UCL Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, United Kingdom.
Hadi ManjiFrom the Department of Neurology (E.J., S.F.K.L., F.J., D.P.K., A.B.), Royal Free Hospital NHS Foundation Trust; The National Hospital for Neurology and Neurosurgery (E.J., F.J., H.M., A.B.), University College London Hospitals NHS Foundation Trust; and Division of Neuropathology (F.R., S.B.), UCL Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, United Kingdom.
Amit BatlaFrom the Department of Neurology (E.J., S.F.K.L., F.J., D.P.K., A.B.), Royal Free Hospital NHS Foundation Trust; The National Hospital for Neurology and Neurosurgery (E.J., F.J., H.M., A.B.), University College London Hospitals NHS Foundation Trust; and Division of Neuropathology (F.R., S.B.), UCL Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, United Kingdom.ORCID 0000-0001-8952-2160
University College London Hospitals NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 61-year-old man from India was admitted to hospital after being found unresponsive by the roadside. He was treated with dual-antiplatelet therapy for an acute coronary syndrome. Ten days into admission, he had mild left-sided face, arm, and leg weakness, which progressed significantly over the next 2 months in association with progressive white matter abnormalities on brain MRI. In this case study, we outline our clinical reasoning, which led to the detection of a rare underlying cause of a devastating neurologic disease. We also present our approach to treatment, which achieved a sustained clinical and radiologic response.

Indexed as

HIV InfectionsWhite MatterClinical ReasoningHumansIndiaMaleMiddle AgedParesis

Identifiers

PMID36797059
PMCPMC10264047
OpenAlexW4321018813

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.