Evidence map›Paper›PMID 36797027›Full record

ArticleAJNR. American journal of neuroradiology2023

Parieto-Occipital Injury on Diffusion MRI Correlates with Poor Neurologic Outcome following Cardiac Arrest.

E Calabrese, S Gandhi, J Shih, M Otero, D Randazzo, C Hemphill, R Huie, J F Talbott, E Amorim

Abstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

E CalabreseFrom the Department of Radiology and Biomedical Imaging (E.C., S.G., J.F.T.).ORCID 0000-0002-1464-0354
S GandhiFrom the Department of Radiology and Biomedical Imaging (E.C., S.G., J.F.T.).
J ShihDepartment of Neurology (J.S., M.O., D.R., C.H., E.A.), Weill Institute for Neurosciences.ORCID 0000-0002-8651-7806
M OteroDepartment of Neurology (J.S., M.O., D.R., C.H., E.A.), Weill Institute for Neurosciences.
D RandazzoDepartment of Neurology (J.S., M.O., D.R., C.H., E.A.), Weill Institute for Neurosciences.ORCID 0000-0003-1185-7504
C HemphillDepartment of Neurology (J.S., M.O., D.R., C.H., E.A.), Weill Institute for Neurosciences.ORCID 0000-0003-4019-7525
R HuieDepartment of Neurological Surgery (R.H.), University of California, San Francisco, San Francisco, California.ORCID 0000-0001-5594-4277
J F TalbottFrom the Department of Radiology and Biomedical Imaging (E.C., S.G., J.F.T.).ORCID 0000-0003-3943-5530
E AmorimDepartment of Neurology (J.S., M.O., D.R., C.H., E.A.), Weill Institute for Neurosciences edilbertoamorim@gmail.com.ORCID 0000-0001-6972-5622

Funding

Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1M
Institutional Career Development Core SupplementKL2TR001870 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SARKAR, URMIMALA · 2016 to 2025
$19.7M
Physiology-driven seizure management post-cardiac arrestK23NS119794 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AMORIM, EDILBERTO · 2021 to 2025
$1.1M
NCATS NIH HHS KL2 TR001870NCATS NIH HHS UL1 TR001872NINDS NIH HHS K23 NS119794
6 · The paper itself

Abstract

background and purposeMR imaging of the brain provides unbiased neuroanatomic evaluation of brain injury and is useful for neurologic prognostication following cardiac arrest. Regional analysis of diffusion imaging may provide additional prognostic value and help reveal the neuroanatomic underpinnings of coma recovery. The purpose of this study was to evaluate global, regional, and voxelwise differences in diffusion-weighted MR imaging signal in patients in a coma after cardiac arrest. MATERIALS AND

methodsWe retrospectively analyzed diffusion MR imaging data from 81 subjects who were comatose for >48 hours following cardiac arrest. Poor outcome was defined as the inability to follow simple commands at any point during hospitalization. ADC differences between groups were evaluated across the whole brain, locally by using voxelwise analysis and regionally by using ROI-based principal component analysis.

resultsSubjects with poor outcome had more severe brain injury as measured by lower average whole-brain ADC (740 [SD, 102] × 10

conclusionsBrain injury affecting the parieto-occipital region measured with quantitative ADC analysis was associated with poor outcomes after cardiac arrest. These results suggest that injury to specific brain regions may influence coma recovery.

Indexed as

Brain InjuriesCraniocerebral TraumaHeart ArrestBrainComaDiffusion Magnetic Resonance ImagingHumansPrognosisRetrospective Studies

Identifiers

PMID36797027
PMCPMC10187825

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.