Trial reportThe European respiratory journal2023
Lung volume reduction surgery
Trial report in The European respiratory journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Pooled it
- Sustained Clinical Benefits of Spiration Valve System in Patients with Severe Emphysema: 24-Month Follow-Up of EMPROVE.Annals of the American Thoracic Society · 2024Trial
- The efficacy-invasiveness trade-off: a retrospective cohort comparison of surgical operation and endobronchial valves for refractory lung bullae disease.BMC pulmonary medicine · 2026Observational
- Connecting the dots: historical perspective on lung volume reduction.Journal of thoracic disease · 2026Review
- Endobronchial Valves for Bronchoscopic Lung Volume Reduction in Severe Emphysema: A Reversible and Non-Surgical Treatment for Patients Who May or May Not Be Candidates for Lung Transplantation.Diagnostics (Basel, Switzerland) · 2026Review
- Is pulmonary hypertension still a contraindication for lung volume reduction?-a narrative review of contemporary evidence.Annals of translational medicine · 2026Review
- Low mortality and favourable outcome in lung volume reduction surgery for different emphysema morphologies.The European respiratory journal · 2026Article
- Association Between Subsegmental Dosing Accuracy and Outcomes of Bronchoscopic Thermal Vapor Ablation: An Exploratory Retrospective Study in Severe Heterogeneous Emphysema.International journal of chronic obstructive pulmonary disease · 2026Article
- Reduction of low attenuation areas of emphysema after lung volume reduction surgery compared to bronchoscopic lung volume reduction with valves.BMC pulmonary medicine · 2025Article
- A Comprehensive Approach to Lung Volume Reduction Encompassing Surgical and Endobronchial Treatment of Severe Emphysema.CHEST pulmonary · 2025Article
- Endobronchial Valve Therapy vs Lung Volume Reduction Surgery in the United States.The Annals of thoracic surgery · 2025Article
- Surgical lung volume reduction eligibility in an emphysema patient pool referred for endoscopic treatment.BMC pulmonary medicine · 2025Observational
- Article
- Unilateral Hyperlucent Lung Syndrome (Swyer-James-Macleod Syndrome) Managed by Video-Assisted Thoracoscopic Surgery.Annals of thoracic surgery short reports · 2025Article
- Multidisciplinary Evaluation for COPD Management.Respiratory care · 2025Article
- Bronchoscopic Lung Volume Reduction: A Narrative Review and Proposal for the Inclusion Criteria.Journal of clinical medicine · 2025Review
- Leptin and Insulin in COPD: Unveiling the Metabolic-Inflammatory Axis-A Narrative Review.Journal of clinical medicine · 2025Review
- Two-year Results of Bronchoscopic Lung Volume Reduction Using One-Way Endobronchial Valves: Real-World Single Center Data.International journal of chronic obstructive pulmonary disease · 2025Article
- Robotic-Assisted Bronchoscopy for Volume Reduction of Giant Emphysematous Bulla: A Case Report.International journal of chronic obstructive pulmonary disease · 2025Article
- Outcomes of lung volume reduction surgery for emphysema: unilateral and bilateral.Journal of thoracic disease · 2024Article
Corrections and comments
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Authors and funding
22 authors at 9 institutions in 2 countries.
Funding
Abstract
backgroundLung volume reduction surgery (LVRS) and bronchoscopic lung volume reduction (BLVR) with endobronchial valves can improve outcomes in appropriately selected patients with emphysema. However, no direct comparison data exist to inform clinical decision making in people who appear suitable for both procedures. Our aim was to investigate whether LVRS produces superior health outcomes when compared with BLVR at 12 months.
methodsThis multicentre, single-blind, parallel-group trial randomised patients from five UK hospitals, who were suitable for a targeted lung volume reduction procedure, to either LVRS or BLVR and compared outcomes at 1 year using the i-BODE score. This composite disease severity measure includes body mass index, airflow obstruction, dyspnoea and exercise capacity (incremental shuttle walk test). The researchers responsible for collecting outcomes were masked to treatment allocation. All outcomes were assessed in the intention-to-treat population.
results88 participants (48% female, mean±sd age 64.6±7.7 years, forced expiratory volume in 1 s percent predicted 31.0±7.9%) were recruited at five specialist centres across the UK and randomised to either LVRS (n=41) or BLVR (n=47). At 12 months follow-up, the complete i-BODE was available in 49 participants (21 LVRS/28 BLVR). Neither improvement in the i-BODE score (LVRS -1.10±1.44
conclusionOur findings do not support the hypothesis that LVRS is a substantially superior treatment to BLVR in individuals who are suitable for both treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.