Evidence map›Paper›PMID 36796803›Full record

ArticleArchives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists2023

Motor Symptom Asymmetry Predicts Cognitive and Neuropsychiatric Profile Following Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease: a 5-Year Longitudinal Study.

Philippe Voruz, Claire Haegelen, Frédéric Assal, Sophie Drapier, Dominique Drapier, Paul Sauleau, Marc Vérin, Julie A Péron

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Is motor asymmetry a predictor of non-motor outcomes in Parkinson's disease?Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  2. Article
  3. Article
  4. Pallidothalamic Circuit-Selective Manipulation Ameliorates Motor Symptoms in a Rat Model of Parkinsonian.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Philippe VoruzClinical and Experimental Neuropsychology Laboratory, Faculty of Psychology, Geneva, Switzerland.ORCID 0000-0001-6796-8807
Claire HaegelenNeurosurgery Department, Pontchaillou University Hospital, Rennes, France.
Frédéric AssalNeurology Department, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
Sophie Drapier'Behavior and Basal Ganglia' Research Unit, University of Rennes 1, Rennes, France.
Dominique Drapier'Behavior and Basal Ganglia' Research Unit, University of Rennes 1, Rennes, France.
Paul Sauleau'Behavior and Basal Ganglia' Research Unit, University of Rennes 1, Rennes, France.
Marc Vérin'Behavior and Basal Ganglia' Research Unit, University of Rennes 1, Rennes, France.
Julie A PéronClinical and Experimental Neuropsychology Laboratory, Faculty of Psychology, Geneva, Switzerland.
Hôpital Pontchaillou · FRUniversity Hospital of Geneva · CHCentre Hospitalier Guillaume Régnier · FRInserm · FR

Funding

Neurology Department of Rennes University Hospital, FranceSwiss National Foundation 105314_182221
6 · The paper itself

Abstract

introductionRisk factors (e.g., motor symptom asymmetry) for short- and long-term cognitive and neuropsychiatric symptoms following deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease have yet to be fully identified. The objectives of the present study were to determine whether motor symptom asymmetry in Parkinson's disease is one such risk factor and to identify predictors of subnormal cognitive decline.

methodsA total of 26 patients receiving STN-DBS (13 with left-sided motor symptoms and 13 with right-sided ones) underwent follow-up neuropsychological, depression and apathy assessments over a 5-year period. Nonparametric intergroup comparisons were performed on raw scores, as well as Cox regression analyses on standardized Mattis Dementia Rating Scale scores.

resultsCompared with patients who had predominantly left-sided symptoms, right-sided patients scored higher on both apathy (at 3 months and 36 months) and depressive symptoms (at 6 months and 12 months) and scored lower on global cognitive efficiency (at 36 months and 60 months). Survival analyses revealed that only right-sided patients had subnormal standardized dementia scores, which were negatively associated with the number of perseverations in the Wisconsin Card Scoring Test.

conclusionRight-sided motor symptoms are a risk factor for more severe short- and long-term cognitive and neuropsychiatric symptoms following STN-DBS, confirming literature findings on left hemispheric vulnerability.

Indexed as

Deep Brain StimulationParkinson DiseaseSubthalamic NucleusCognitionHumansLongitudinal StudiesNeuropsychological TestsTreatment OutcomeCognitionCognitive vulnerabilityLeft hemisphereMotor symptom asymmetrySTN-DBS

Identifiers

PMID36796803
PMCPMC10456213
OpenAlexW4321018838

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.